Sökning: "antiviral agents"

Visar resultat 1 - 5 av 25 avhandlingar innehållade orden antiviral agents.

1. 1. Design and Synthesis of Sialic Acid Conjugates as Inhibitors of EKC-causing Adenoviruses

   Författare :Susanne Johansson; Jan Kihlberg; Mikael Elofsson; Stefan Oscarson; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Sialic acid; sialylmimetics; sialylation; multivalency; glycoconjugates; adenovirus; antiviral agents; epidemic keratoconjunctivitis; Bioorganic chemistry; Bioorganisk kemi;

   Sammanfattning : The combat against viral diseases has been, and still is, a major challenge in the field of drug development. Viruses are intracellular parasites that use the host cell ma-chinery for their replication and release. Therefore it is difficult to target and destroy the viral particle without disturbing the essential functions of the host cell. LÄS MER

3. 2. Adenovirus-host interactions : implications for tropism and therapy

   Författare :Annasara Lenman; Niklas Arnberg; Lennart Svensson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adenoviridae; Amino Acids; Antiviral Agents; Epithelial Cells; Factor IX;

   Sammanfattning : Human adenoviruses (HAdVs) are common viruses often associated withgastrointestinal, ocular and respiratory infections. They can infect a widevariety of cells, both dividing and non-dividing. HAdVs attach to and infecttarget cells through interactions with cellular receptors. LÄS MER

4. 3. Interaction of herpes simplex virus with cell surface glycosaminoglycans as a target for antiviral intervention

   Författare :Kicki Bergefall; Göteborgs universitet; []
   Nyckelord :HSV; glycoproteins; glycosaminoglycans; virus receptor; antiviral drugs;

   Sammanfattning : Herpes simplex virus (HSV) infections in humans are predominantly manifested as oral cold sores or genital ulcers. As HSV infects cells by interaction with cell surface heparan sulfate (HS) and/or chondroitin sulfate (CS), the aim of the research work presented in this thesis was to explore the possibility of antiviral intervention with compounds that mimic HS or CS. LÄS MER

5. 4. The glycobiology of human adenovirus infections : implications for tropism and treatment

   Författare :Naresh Chandra; Niklas Arnberg; Lars Frängsmyr; Gunnel Haldén; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; denovirus; cellular receptor; glycosaminoglycan; sialic acid; decoy receptors; tropism; epidemic keratoconjunctivitis; antiviral drugs; GAG-mimetic; obesity; medicinsk virologi; Medical Virology;

   Sammanfattning : Human adenoviruses (HAdVs) are common human pathogens, causing gastrointestinal, ocular, and respiratory infections on a regular basis. Epidemic keratoconjunctivitis (EKC) is a severe ocular infection for which no approved antivirals are available. LÄS MER

7. 5. Novel vaccines and antiviral treatments for enterovirus induced infections and disease

   Författare :Marta Butrym; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Enterovirus infections are common around the world and can impact people’s lives in various ways, causing pancreatitis, myocarditis, common cold and more. This thesis is focused on testing the effectiveness of new vaccines and an antiviral agent in the context of cystic fibrosis (CF) and type 1 diabetes (T1D). LÄS MER