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Visar resultat 21 - 25 av 108 avhandlingar som matchar ovanstående sökkriterier.

  1. 21. Preclinical PET imaging and therapy of Alzheimer's disease

    Författare :Silvio R. Meier; Stina Syvänen; Dag Sehlin; Greta Hultqvist; Matthias Brendel; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; amyloid-beta; positron emission tomography PET ; bispecific antibody; BACE-1; TREM2; GFAP; Molekylär medicin; Molecular Medicine; Neuroscience; Neurovetenskap;

    Sammanfattning : The main histopathological hallmarks of Alzheimer’s disease are extracellular amyloid-beta (Aβ) plaques and intracellular neurofibrillary tangles, containing tau protein. Because of misfolded and aggregated proteins, activated microglia and astroglia react with a neuroinflammatory response, which may contribute to disease progression and severity. LÄS MER

  3. 22. Brain distribution of a bispecific antibody targeting Aβ

    Författare :Gustavsson Tobias; Dag Sehlin; Stina Syvänen; Paul O'Callaghan; Danica Stanimirovic; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; amyloid-beta; blood-brain barrier; single-photon emission computed tomography SPECT ; bispecific antibody; immunotherapy; Molekylär medicin; Molecular Medicine; Neuroscience; Neurovetenskap;

    Sammanfattning : Alzheimer’s disease (AD) is characterised by aberrant protein aggregation in the brain with subsequent synaptic loss, neuroinflammation, and brain atrophy that ultimately clinically manifests as cognitive impairment. Histopathological findings in AD are extracellular plaques of the protein amyloid-beta (Aβ), Aβ in blood vessels (CAA), and intracellular neurofibrillary tangles (NFT) of hyperphosphorylated tau. LÄS MER

  4. 23. Interplay between autophagy and amyloid beta metabolism in Alzheimer’s disease

    Författare :Richeng Jiang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer’s disease (AD), the most common neurodegenerative disease, is characterized by two pathological hallmarks: extracellular amyloid-beta peptide (Aβ) plaque depositions and neurofibrillary tangles (NFTs) composed of intracellular hyperphosphorylated tau aggregations. A cellular degradation system, autophagy is additionally dysfunctional in AD and plays a key role in Aβ and tau metabolisms. LÄS MER

  5. 24. To Fold or To Fibrillate? Serendipity in Stability Studies

    Författare :Olga Szczepankiewicz; Biofysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein stability; protein reconstitution; protein aggregation; Monellin; PGB1; Split-GFP; Amyloid beta;

    Sammanfattning : Proteins are complex structures and years of research have been spent on attempts to understand their complexity. The non-covalent interactions involved in protein folding are: hydrophobic effect, electrostatic interactions, van der Waals interactions and hydrogen bonding. LÄS MER

  7. 25. Spectroscopic studies of dynorphin neuropeptides and the amyloid beta-peptide : The consequences of biomembrane interactions

    Författare :Loïc Hugonin; Astrid Gräslund; Bernard Lebleu; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biophysics; Biofysik; Biophysics; biofysik;

    Sammanfattning : Dynorphin A, dynorphin B and big dynorphin are endogenous opioid neuropeptides. They play an important role in a wide variety of physiological functions such as regulation of pain processing and memory acquisition. Such actions are generally mediated through the κ-receptors. LÄS MER