Sökning: "megakaryocytes"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet megakaryocytes.

  1. 1. The diverse role of laminin isoforms in neuronal cells, human mast cells and blood platelets

    Författare :Wondossen Sime; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Laminins; extracellular matrix; integrins; tooth pulp fibroblasts; mast cells; megakaryocytes; platelets; cell adhesion; cell migration; neurite outgrowth;

    Sammanfattning : The close interaction of cells with other cells and with extracellular matrix (ECM) components is a prerequisite in a number of biological activities. During development of the nervous system, axons often navigate a considerable distance depending on the type of molecular factors they encounter. LÄS MER

  3. 2. The mutational landscape and microenvironment in myelodysplastic syndromes with deletion of chromosome 5q

    Författare :Christian Scharenberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Myelodysplastic Syndromes (MDS) with deletion of chromosome 5q (del(5q) are malignant bone marrow disorders characterized by macrocytic anemia, chronic transfusion dependency and an increased risk of progression to acute myeloid leukemia. A high proportion of patients with lower-risk del(5q) myelodysplastic syndromes will respond to lenalidomide treatment, but more than 40% of patients have progressed to acute leukemia five years after starting treatment. LÄS MER

  4. 3. Angiogenesis in myeloproliferative disorders

    Författare :Eva Zetterberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The chronic myeloproliferative disorders, comprising polycythemia vera (PV), essential thrombocytosis (ET), chronic myeloid leukaemia (CML) and myelofibrosis (MF), are all characterized by pathological angiogenesis in variable degrees, e.g. increased microvascular density (MVD) and bizarre vessel architecture. LÄS MER

  5. 4. Platelet angiogenic activities and their regulation on endothelial progenitor cell functions

    Författare :Zhangsen Huang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Platelets are essential for haemostasis and thrombosis, but also play a major role in angiogenesis. Activated platelets recruit progenitor cells and induce differentiation into endothelial progenitor cells (EPCs), which contribute importantly to vascular regeneration and endothelium reparation. LÄS MER

  7. 5. Human Bone Marrow Microenvironment in Health and Disease

    Författare :Sandro Bräunig; Avdelningen för molekylär hematologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoietic microenvironment; Imaging; Myeloproliferative neoplasms; Spatial relationships; acute lymphoblastic leukaemia ALL ; Fibrosis; Mesenchymal stromal cell; Single cell RNA sequencing;

    Sammanfattning : Hematopoietic stem cells (HSCs) are safeguarded from various threats such as stress, injury, or radiationwithin specialized microenvironments or niches within the bone marrow. In this thesis, we investigatedvarious facets of the bone marrow (BM) microenvironment and its critical role in hematopoiesis andrelated disorders. LÄS MER