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Visar resultat 1 - 5 av 10 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Coronary heart disease in women : diagnostic and prognostic markers

   Författare :Faris al-Khalili; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :women; coronary artery disease; diabetes mellitus; blood lipids; coronary angiography; exercise testing; intravascular ultrasound; oestrogen;

   Sammanfattning : The main part of this thesis investigated a cohort of women younger than 66 years who had recovered from an event of acute coronary syndrome. It assessed the relationship between traditional coronary risk factors, basic clinical parameters, exercise testing results, coronary angiographic findings and recurrent cardiac events during a five-year follow up period. LÄS MER

3. 2. Gene regulation, intracellular signaling and membrane traffic : studies in primary human skeletal muscle cultures

   Författare :Lubna Al-Khalili; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Skeletal muscle cultures; insulin signal transduction; glucose transport; GLUT4; RNAi; Na ; K -ATPase; MEF2;

   Sammanfattning : Skeletal muscle is an insulin sensitive organ and plays a major role in whole body electrolyte and substrate homeostasis in the post prandial state. Impaired insulin action in skeletal muscle may lead to the pathological condition of insulin resistance. LÄS MER

4. 3. Electron impact dissociation of molecular ions at CRYRING

   Författare :Ahmed Al-Khalili; Ronald A Phaneuf; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physics; fysik;

   Sammanfattning : In this thesis, the electron impact dissociation of molecular ions has been studied using the ion storage ring CRYRING at Manne Siegbahn Laboratory in Stockholm, Sweden. The electron impact dissociation of molecular ions occurs via many processes, which lead to different charge states of the product fragments. LÄS MER

5. 4. Exploring genetic heterogeneity in cancer using high-throughput DNA and RNA sequencing

   Författare :Erik Fasterius; Cristina Al-Khalili Szigyarto; Mathias Uhlén; Peter-Bram ’t Hoen; KTH; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Biotechnology; bioinformatics; RNA-seq; WGS; WES; systems biology; variant analysis; single nucleotide variant; gene expression; machine learning; clustering; open source; R; bioconductor; Python; Bioteknologi; Biotechnology;

   Sammanfattning : High-throughput sequencing (HTS) technology has revolutionised the biomedical sciences, where it is used to analyse the genetic makeup and gene expression patterns of both primary patient tissue samples and models cultivated in vitro. This makes it especially useful for research on cancer, a disease that is characterised by its deadliness and genetic heterogeneity. LÄS MER

7. 5. The relationship between orthology, protein domain architecture and protein function

   Författare :Kristoffer Forslund; Erik Sonnhammer; Cristina Al-Khalili Szigyarto; Sarah Teichmann; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; homology; orthology; paralogy; gene duplications; protein function prediction; low-complexity regions; protein domains; domain architecture evolution; introns; intron position conservation; orthology conjecture; domain grammar hypothesis; biokemi; inriktning teoretisk kemi; Biochemistry with Emphasis on Theoretical Chemistry;

   Sammanfattning : Lacking experimental data, protein function is often predicted from evolutionary and protein structure theory. Under the 'domain grammar' hypothesis the function of a protein follows from the domains it encodes. LÄS MER