Sökning: "Skeletal muscle cultures"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden Skeletal muscle cultures.

  1. 1. Mathematical Modelling of Insulin Signalling : Effects on Glucose Metabolism in Skeletal Muscle

    Författare :Peter Sögård; Högskolan i Skövde; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Naturvetenskap; Natural sciences;

    Sammanfattning : The use of models to understand complex phenomena is indispensable to the scientific community. The advantage of a model is that it simplifies the phenomena under study. However, a model should be only as complex as required, no more, no less. LÄS MER

  3. 2. Gene regulation, intracellular signaling and membrane traffic : studies in primary human skeletal muscle cultures

    Författare :Lubna Al-Khalili; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Skeletal muscle cultures; insulin signal transduction; glucose transport; GLUT4; RNAi; Na ; K -ATPase; MEF2;

    Sammanfattning : Skeletal muscle is an insulin sensitive organ and plays a major role in whole body electrolyte and substrate homeostasis in the post prandial state. Impaired insulin action in skeletal muscle may lead to the pathological condition of insulin resistance. LÄS MER

  4. 3. Peroxisome proliferator-activated receptor delta : regulation of skeletal muscle metabolism

    Författare :David Kitz Krämer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Peroxisome Proliferator-Activated Receptor PPAR 4 insulin sensitivity; insulin action; human skeletal muscle; primary cultured muscle cells; lipid-metabolism; glucose metabolism; AMP activated protein kinase AMPK ; Type 2 Diabetes Mellitus;

    Sammanfattning : Peroxisome Proliferator-Activated Receptor (PPAR) δ is a nuclear transcription factor which has been implicated in the regulation of lipid metabolism in skeletal muscle. In addition to the postural and locomotive functions of skeletal muscle, this organ has a major impact role on whole body metabolism. LÄS MER

  5. 4. The role of steroid hormones in skeletal muscle metabolism

    Författare :Firoozeh Salehzadeh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Steroid hormones play important roles in the regulation of whole body metabolism. Skeletal muscle is an insulin-responsive organ with a key role in overall substrate metabolism. Disturbances in skeletal muscle metabolism, as a result of hormonal imbalance may be an underlying defect in metabolic disease. LÄS MER

  7. 5. The metabolic syndrome : studies on thrifty genes

    Författare :Katja Kannisto; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adipose tissue; adiponectin; 11beta-hydroxysteroid dehydrogenase type 1; BMI; glucocorticoid; GLUT; HAART; HIV; IL-6; insulin; insulin resistance; LDL-cholesterol; leptin; lifestyle; lipodystrophy; LPL; obesity; PPAR; PGC-1; polymorphism; rosiglitazone; skeletal muscle; twins;

    Sammanfattning : The metabolic syndrome consists of a cluster of atherogenic risk factors that include insulin resistance, glucose intolerance, hyperglycemia, dyslipidemia, obesity and a procoagulant state with impaired fibrinolysis. Genetic factors might predispose to the metabolic syndrome while the increasing prevalence of visceral and abdominal obesity linked to the shift to more sedentary lifestyles exacerbates the manifestation. LÄS MER