Sökning: "MEF2"

Hittade 5 avhandlingar innehållade ordet MEF2.

1. 1. Gene regulation, intracellular signaling and membrane traffic : studies in primary human skeletal muscle cultures

   Författare :Lubna Al-Khalili; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Skeletal muscle cultures; insulin signal transduction; glucose transport; GLUT4; RNAi; Na ; K -ATPase; MEF2;

   Sammanfattning : Skeletal muscle is an insulin sensitive organ and plays a major role in whole body electrolyte and substrate homeostasis in the post prandial state. Impaired insulin action in skeletal muscle may lead to the pathological condition of insulin resistance. LÄS MER

3. 2. Metabolic and mitogenic transduction cascades in skeletal muscle : implications for exercise effects on glucose metabolism and gene regulation

   Författare :Mei Yu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Exercise; skeletal muscle; glucose homeostasis; insulin signal transduction; gene regulation; MAPK cascades; AMPK; MEF2-DNA binding.;

   Sammanfattning : Level of physical activity is linked to improved glucose homeostasis. The molecular signaling mechanisms by which insulin and exercise/muscle contractions lead to increased glucose transport and metabolism and gene expression have not been completely elucidated. LÄS MER

4. 3. Salt-inducible kinase 1 : a novel regulator within a cell sodium-sensing network

   Författare :Karin Stenström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Na ; K -ATPase; -adducin; Milan hypertensive and normotensive strain of rats; hypertension; angiotensin II; cardiac hypertrophy; myocyte enhancer factor-2 and nuclear factor of activated T-cells;

   Sammanfattning : Na+, K+-ATPase (NK) is expressed in all animal cells and plays a crucial role in cellular ion homeostasis. The NK activity is tightly regulated by specific signaling networks that must be well controlled in time and space (at the plasma membrane or in the intracellular compartments) to guarantee the specificity of the physiological response. LÄS MER

5. 4. Identification of downstream targets of Alk signaling in Drosophila melanogaster

   Författare :Gaurav Varshney; Ruth Palmer; Udo Hacker; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drosophila; Alk; Jeb; visceral muscles; somatic muscles; Delilah; Goliath; Hand; Molecular biology; Molekylärbiologi;

   Sammanfattning : The Drosophila gene Anaplastic lymphoma kinase (Alk) is homologous to mammalian ALK, a member of the Alk/Ltk family of receptor tyrosine kinases. In Drosophila Alk is crucial for development of the embryonic visceral mesoderm, where it is the receptor for Jelly Belly (Jeb) ligand. LÄS MER

7. 5. Relevance of the salt-inducible kinase network for the development of high blood pressure and cardiac hypertrophy

   Författare :Sergej Popov; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Hypertension (high blood pressure) is a multifactorial condition that remains a big worldwide problem. 95% of all hypertensive people suffer from essential hypertension with unknown causes. This can cause different heart diseases such as cardiac hypertrophy (CH), a condition which can ultimately lead to heart failure. LÄS MER