Sökning: "Universal vaccine"

Visar resultat 1 - 5 av 12 avhandlingar innehållade orden Universal vaccine.

  1. 1. Broadly protective nanoparticle-based mucosal vaccine against influenza virus infection

    Författare :Valentina Bernasconi; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mucosal vaccination; Influenza A virus; CTA1-DD; Nanoparticle; Targeted adjuvant; Nasal immunization; Oral immunization; Neonatal vaccine; Universal vaccine;

    Sammanfattning : Influenza is one of the major viral diseases affecting humans and it is responsible for three to five million cases of severe illness and about 250.000 to 500.000 deaths each year worldwide. LÄS MER

  3. 2. Lung-resident, M2e-specific CD4 T cells critically protect during influenza infection

    Författare :Ajibola Omokanye; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; influenza; vaccine; universal; heterosubtypic; M2e; CD4; Th17; ThCTL; tissue-resident; cytotoxic; single-cell RNA-seq;

    Sammanfattning : Memory CD4+ T cells are a critical component of the adaptive immune response to fight infection. However, current vaccines against influenza only focus on the other arm of adaptive immunity—triggering B cells to produce antibodies. LÄS MER

  4. 3. Development of novel DNA vaccine and immunotherapeutic approaches

    Författare :Maroof Hasan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Many potential DNA vaccination and immunotherapeutic strategies has been explored in both animal models and human settings in recent years. However, the failure of efficient and safe method development suggests that it is time to rethink, since more innovative approaches are needed for better control of infection and immunotherapy. LÄS MER

  5. 4. Proximity Extension Assay : a universal tool for proteomics in precision medicine

    Författare :Phathutshedzo M. Muthelo; Ulf Landegren; Jochen Schwenk; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proximity Extension Assay; Precision medicine; Assay development; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi;

    Sammanfattning : Precision medicine aims to utilise biomarkers to ensure the right treatment is given to the right patient at the right time. In pursuit of this goal, sensitive protein detection is essential to improve opportunities for discovery, verification, validation and development of valuable protein biomarkers. LÄS MER

  7. 5. Analytical Quality by Design Method Development for Vaccine Characterization

    Författare :Lars Geurink; Catharina Sänger van de Griend; Mikael Hedeland; Martijn Schenning; Iulia Oita; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; viral vaccines; adenovirus; influenza; polio; COVID; corona; capillary electrophoresis; analytical quality by design; analytical method development; CGE; icIEF; CZE; crude cell suspension analysis; in-process sample analysis; quality control testing; biopharmaceutical characterization; Analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Sammanfattning : Vaccines that are safe, efficacious, and can be rapidly developed are needed to prevent and to react to emerging global infectious disease threats such as influenza, Polio, and Coronavirus diseases. Fast and reliable analytical methods are required without delay to support vaccine process and product development, characterization, and quality control testing. LÄS MER