Sökning: "Jochen Schwenk"
Visar resultat 1 - 5 av 11 avhandlingar innehållade orden Jochen Schwenk.
1. Affinity assays for profiling disease-associated proteins in human plasma
Sammanfattning : Affinity-based proteomics offers opportunities for the discovery and validation of disease-associated proteins in human body fluids. This thesis describes the use of antibody-based immunoassays for multiplexed analysis of proteins in human plasma, serum and cerebrospinal fluid (CSF). LÄS MER
2. On the application and validation of multiplexed affinity assays
Sammanfattning : Proteins are essential macromolecules that carry out complex functions in human cells, tissues, and organs. They regulate a diverse set of biological processes and protect against pathogens. However, dysregulation or malformation of proteins can cause disease. LÄS MER
3. Antibody-based bead arrays for high-throughput protein profiling in human plasma and serum
Sammanfattning : Affinity-based proteomics utilizes affinity binders to detect target proteins in a large-scale manner. This thesis describes a high-throughput method, which enables the search for biomarker candidates in human plasma and serum. LÄS MER
4. Neuroproteomic profiling of human body fluids
Sammanfattning : This thesis provides results from affinity based studies where human body fluids were profiled to find markers for neurological diseases. Both proteins and autoantibodies were analysed using microarray technologies that can profile hundreds of analytes and hundreds of samples in parallel using small sample volumes. LÄS MER
5. On the profiling of autoantibodies in psychiatric disorders
Sammanfattning : There is a great need to increase our understanding of diseases affecting the brain and their underlying pathogenic mechanisms. To address this need, the work presented in this thesis applied affinity based proteomic techniques to profile proteins, and to investigate protein profiles and the autoantibody repertoire in brain related disorders. LÄS MER