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Visar resultat 1 - 5 av 93 avhandlingar som matchar ovanstående sökkriterier.
1. TRAF6 stimulates TGFβ-induced oncogenic signal transduction in cancer cells
Sammanfattning : Prostate cancer is one of the leading causes of cancer-related deaths in men worldwide, with 10,000 new cases/year diagnosed in Sweden. In this context, there is an urgent need to identify new biomarkers to detect prostate cancer at an initial stage for earlier treatment intervention. LÄS MER
2. TGFβ and LXR signaling in hepatocellular carcinoma
Sammanfattning : Hepatocellular carcinoma (HCC) is one of the most prevalent cancer types in the Western world and in the Asia-pacific regions, with its incidence expected to rise up to 22 million cases till 2020. Hepatocellular carcinoma etiology is mainly due to hepatitis B (HBV) and hepatitis C (HCV) infections, and to a lesser extent it is determined by the development of alcohol-driven cirrhosis and non-alcoholic steatohepatitis (NASH). LÄS MER
3. Non-canonical TGFb signaling pathways in prostate cancer
Sammanfattning : Prostate cancer is the second leading cause of cancer-related death in men in the Western world. Deregulation of transforming growth factor β (TGFβ) signaling pathway is frequently detected in prostate cancer and contributes to tumor growth, migration, and invasion. LÄS MER
4. Gene regulation by different proteins of TGFβ superfamily
Sammanfattning : The present thesis discusses how gene regulation by transforming growth factor β (TGFβ) family cytokines is affected by post-translational modifications of different transcription factors. The thesis also focuses on gene regulation by transcription factors involved in TGFβ signaling. LÄS MER
5. Role of TGFβ-induced hyaluronan-CD44 signaling in cancer progression
Sammanfattning : Hyaluronan, a prevalent glycosaminoglycan of the extracellular space often accumulates in pathological conditions, such as chronic inflammation, infection, and cancer. Hyaluronan synthase HAS2 has been responsible for the synthesis and deposition of hyaluronan in a variety of tumors. LÄS MER