Sökning: "αSMA"

Hittade 3 avhandlingar innehållade ordet αSMA.

  1. 1. TGFβ and LXR signaling in hepatocellular carcinoma

    Författare :Claudia Bellomo; Aristidis Moustakas; Lars Holmgren; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Hepatocellular Carcinoma; high-throughput imaging; small molecules; epithelial plasticity; LXR; Snail; TGFβ; tumor suppression; reactive oxygen species; cancer-associated fibroblast; myofibroblast; Smad3; αSMA;

    Sammanfattning : Hepatocellular carcinoma (HCC) is one of the most prevalent cancer types in the Western world and in the Asia-pacific regions, with its incidence expected to rise up to 22 million cases till 2020. Hepatocellular carcinoma etiology is mainly due to hepatitis B (HBV) and hepatitis C (HCV) infections, and to a lesser extent it is determined by the development of alcohol-driven cirrhosis and non-alcoholic steatohepatitis (NASH). LÄS MER

  3. 2. Myofibroblasts and polyploid cells in the conjunctival surface after allogeneic hematopoietic stem cell transplantation

    Författare :David Hallberg; Göteborgs universitet; []
    Nyckelord :Myofibroblast; Polyploid; Allogeneic; Graft-versus-Host Disease;

    Sammanfattning : Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment modality for hematological malignancies, such as leukemia and lymphoma. However, a major complication of the procedure is that the immune effector cells in the graft may become activated towards the host´s healthy tissues, resulting in a condition called Graft-versus-Host Disease (GvHD). LÄS MER

  4. 3. Tumor microenvironment : the paradoxical action of fibroblasts

    Författare :Twana Alkasalias; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The term tumor refers to an abnormal and pathological tissue characterized by a massive cell growth; it comprises various populations of transformed and malignant cells. These cells cross-communicate with each other and with different types of cells in the surrounding microenvironment. LÄS MER