Sökning: "Smad3"

Visar resultat 1 - 5 av 22 avhandlingar innehållade ordet Smad3.

  1. 1. RUNX1/AML1 functions and mechanisms regulating granulocyte-macrophage colony-stimulating factor transcription

    Författare :Hebin Liu; Umeå universitet.; [2005]
    Nyckelord :RUNX1 AML1; Granulocyte-macrophage colony-stimulating factor GM-CSF ; Calcineurin; CaMKII; Ets1; Transforming growth factor-b TGF-b ; Smad3; molekylärbiologi; Molecular Biology;

    Sammanfattning : Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a multipotent cytokine involved in the production and function of hematopoietic cells, and GM-CSF plays in particular a major role in responses to infection and physiological and pathological inflammatory processes. GM-CSF is produced in many cell types, and increases in the intracellular Ca2+ concentration are, like in many other systems, of major importance in the intracellular signaling that determines GM-CSF expression after receptor stimulation of the cells. LÄS MER

  2. 2. TGF-beta signaling in cancer

    Detta är en avhandling från Göteborg : Intellecta Infolog AB

    Författare :Erik Johansson; Göteborgs universitet.; Gothenburg University.; [2010]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-β; proliferation; cancer; tumor suppressor; diffuse-type gastric carcinoma; neuroblastoma; nuclear receptor TLX; cancer stem cell; angiogenesis; ABCG2; VHL; HIF2α; hypoxia; Smad3;

    Sammanfattning : Transforming Growth Factor Beta (TGF-β) is a cytokine regulating a wide range of cellular processes such as proliferation, differentiation, and migration. At the early stages of cancer development TGF-β functions as a tumor suppressor, mainly due to its inhibitory effect on cellular growth, but during cancer progression, mutations in TGF-β signal components switches TGF-β into a promoter of cancer cell proliferation, survival and metastasis. LÄS MER

  3. 3. TGFβ and LXR signaling in hepatocellular carcinoma

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Claudia Bellomo; Uppsala universitet.; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Hepatocellular Carcinoma; high-throughput imaging; small molecules; epithelial plasticity; LXR; Snail; TGFβ; tumor suppression; reactive oxygen species; cancer-associated fibroblast; myofibroblast; Smad3; αSMA;

    Sammanfattning : Hepatocellular carcinoma (HCC) is one of the most prevalent cancer types in the Western world and in the Asia-pacific regions, with its incidence expected to rise up to 22 million cases till 2020. Hepatocellular carcinoma etiology is mainly due to hepatitis B (HBV) and hepatitis C (HCV) infections, and to a lesser extent it is determined by the development of alcohol-driven cirrhosis and non-alcoholic steatohepatitis (NASH). LÄS MER

  4. 4. Molecular studies of pancreatic cancer: Characterization of the transforming growth factor beta signaling pathway

    Detta är en avhandling från Department of Clinical Genetics, Lund University

    Författare :Tord Jonson; Lund University.; Lunds universitet.; [2001]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SMAD4; PCR; FISH; cytogenetics; chromosome; pancreatic cancer; TGFB signaling; cytogenetik; Genetik; Genetics;

    Sammanfattning : In the present thesis, genetic abnormalities in pancreatic cancer were studied, with special emphasis on alterations of components involved in the transforming growth factor beta (TGFB) signaling pathway. In the first study, fluorescence in situ hybridization and cytogenetic analyses revealed aberrations of chromosome 18 in all 13 pancreatic carcinoma cell lines studied, in particular frequent breaks close to the centromere of chromosome arm 18q. LÄS MER

  5. 5. Keloids - A fibroproliferative disease

    Detta är en avhandling från Linköping University Electronic Press

    Författare :Oliver Seifert (Bock); Linköpings universitet.; Linköpings universitet.; [2008]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; keloid; TGF-beta; SMAD; quality of life; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Dermatology and venerology; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Dermatologi och venerologi;

    Sammanfattning : Keloids are a fibroproliferative disorder of unknown etiology developing in the skin after injury or spontaneously. The aim of this thesis is to gain deeper insight into the role of TGF-β and its signaling pathway proteins, SMADs, in the pathogenesis of keloids and describe the gene expression profile in different keloid sites in the search for potential target genes for future treatment. LÄS MER