Sökning: "T-ALL"

Visar resultat 16 - 20 av 24 avhandlingar innehållade ordet T-ALL.

  1. 16. Prognostic factors, treatment and outcome in adult acute lymphoblastic leukemia : Population-based studies in Sweden

    Författare :Piotr Kozlowski; Helene Hallböök; Maria Åström; Anita W. Rijneveld; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute Lymphoblastic Leukemia; adult; chemotherapy; prognosis; population-based; Onkologi; Oncology;

    Sammanfattning : Acute lymphoblastic leukemia (ALL) has poor prognosis in older/elderly adults and in high-risk/relapsed disease. Recommended treatment of ALL was evaluated (study I-IV). Data was obtained from the Swedish Acute Leukemia registries and from patient records.I. LÄS MER

  3. 17. Multi-omic time-series analysis of T-cells as a model for identification of biomarkers, treatments and upstream disease regulators

    Författare :Olof Rundquist; Mika Gustafsson; Colm Nestor; Riitta Lahesmaa; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : CD4+ T-cell function and their process of differentiation is a central piece of the puzzle in a multitude of diseases. CD4+ T-cells are part of the adaptive immune system and function by directing other immune cells to the site of infection and instructing B-cells to produce antibodies, among many other functions. LÄS MER

  4. 18. Multiparameter flow cytometry and minimal residual disease in patients with acute leukemia

    Författare :Elisabet Björklund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Flow cytometry; immunophenotyping; Minimal Residual Disease; acute leukemia; hernatopoietic stem cells;

    Sammanfattning : The investigation of minimal residual disease (MRD) with multiparameter flow cytometry (FC) immunophenotyping has proven to be a powerful approach for disease monitoring in patients with acute leukemia (AL). This technique mainly relies on the identification of minor leukemic cell populations that can be discriminated from their normal counterparts on the basis of phenotypic aberrancies observed at diagnosis. LÄS MER

  5. 19. WILMS’ TUMOUR GENE 1 PROTEIN (WT1) – AN EFFECTOR IN LEUKEMOGENESIS?

    Författare :Karina Vidovic; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; WT1 delZ ; leukemia; BCR ABL1; hematopoiesis; NDRG2; IRF8; WT1;

    Sammanfattning : Wilms’ tumour gene 1 (WT1) encodes a zinc-finger transcription factor functioning as a key regulator in organ development. WT1 was first identified as a tumour suppressor gene due to its inactivation in Wilms’ tumour cases, a childhood kidney cancer. LÄS MER

  7. 20. Notch in cancer and cancer metabolism : six degrees of intracellular turbulence

    Författare :Sebastian K-J Landor; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Notch signaling is an evolutionarily conserved cell-to-cell contact-dependent signaling mechanism in multicellular organisms directing cellular fates both in early development and adult tissues. In metazoans the Notch pathway consists of multiple paralogs of receptors and ligands constituting a complex juxtacrine communications network orchestrating organismal homeostasis. LÄS MER