Sökning: "T-ALL"
Visar resultat 6 - 10 av 24 avhandlingar innehållade ordet T-ALL.
6. DNA methylation in T cell leukaemia
Sammanfattning : T cell acute lymphoblastic leukaemia (T-ALL) is a predominantly paediatric cancer that stems from malignant transformation of developing T cells. While the disease has an overall survival rate of 80%, the intense chemotherapy treatment causes severe toxicity and long-term side effects. LÄS MER
7. Genetic Characterization of Pediatric T-cell Acute Lymphoblastic Leukemia
Sammanfattning : The aim of my thesis has been to characterize genetically pediatric T-cell acute lymphoblastic leukemia (T-ALL). Articles I and II focus on molecular characterization of translocations involving T-cell receptor (TCR) loci. LÄS MER
8. On the role of notch, numb and numblike in development and cancer
Sammanfattning : The development of mutlicellualr organisms relies on a highly conserved signaling network, of which one of the key components is the Notch signaling pathway. The core Notch signaling pathway consists of receptors, ligands and an intracellular mediator. LÄS MER
9. Acute Lymphoblastic Leukaemia in Adult Patients : Studies of Prognostic Factors, Treatment Results and in vitro Cellular Drug Resistance
Sammanfattning : Treatment results and clinical characteristics in adult acute lymphoblastic leukaemia (ALL) were evaluated regarding three issues: a new treatment with cytarabine up-front, stem cell transplantation and a comparison between adult and paediatric treatment protocols. All studies were conducted on a national basis. LÄS MER
10. The role of the tumor suppressor gene, FBW7, and mechanisms of its inactivation in cancer
Sammanfattning : The F-box protein FBW7 is a tumor suppressor and SCF ubiquitin ligase targeting several key oncoproteins for proteasomal degradation. In this thesis we addressed whether the FBW7 gene is inactivated by mutations in various human tumor types and explored alternative mechanism(s) for the inactivation of FBW7. LÄS MER