Sökning: "T-ALL"

Visar resultat 11 - 15 av 24 avhandlingar innehållade ordet T-ALL.

1. 11. Minimal Residual Disease Assessment in Childhood Acute Lymphoblastic Leukemia

   Författare :Ingrid Thörn; Christer Sundström; Richard Rosenquist; Gisela Barbany; Johan Botling; Kjeld Schmiegelow; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Childhood acute lymphoblastic leukemia; minimal residual disease; IG TCR gene rearrangements; BCR-ABL1 fusion gene transcripts; real-time quantitative PCR; multicolor flow cytometry; Pathology; Patologi; Pathology; patologi;

   Sammanfattning : Traditionally, response to treatment in hematological malignancies is evaluated by light microscopy of bone marrow (BM) smears, but due to more effective therapies more sensitive methods are needed. Today, detection of minimal residual disease (MRD) using immunological and molecular techniques can be 100 times more sensitive than morphology. LÄS MER

3. 12. Apoptosis signaling in leukemia and lymphoma: understanding mechanisms of chemoresistance

   Författare :Astrid Ottosson Wadlund; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Apoptosis (programmed cell death) is a basic physiological process, essential in the balance between life and death of cells of normal tissues in the body. Apoptosis can be considered as cellular “suicide” initiated by the cell itself when infected by a virus or transformed into a cancer cell. LÄS MER

4. 13. Cell death mechanisms of anti-cancer agents and treatment response in acute leukemia

   Författare :Edward Laane; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :acute leukemia; glucocorticoids; doxorubicin; apoptosis; autophagy; minimal residual disease; dendritic cells;

   Sammanfattning : Acute leukemia (AL) is a fatal disease, which causes rapid death in the absence of appropriate chemotherapeutic intervention. Long-term survival rates vary from 80% in childhood lymphoblastic AL (ALL) to 10-20% in adult myeloid AL (AML). LÄS MER

5. 14. Studies of Cytotoxic Compounds of Natural Origin and their Mechanisms of Action

   Författare :Jenny Felth; Lars Bohlin; Joachim Gullbo; Ulf Göransson; Thomas Efferth; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cytotoxic; cardiac glycoside; gambogic acid; cancer; mechanism of action; Pharmacognosy; Farmakognosi; Pharmacognosy; Farmakognosi;

   Sammanfattning : Cancer incidence is increasing and novel anticancer drugs with new mechanisms of action are essential for future chemotherapeutic treatment. Natural products have historically played an important role in the development of anti-cancer drugs and have potential to do so also in the future. LÄS MER

7. 15. Genomic characterization of pediatric acute lymphoblastic leukemia by deep sequencing

   Författare :Carl Mårten Lindqvist; Ann-Christine Syvänen; Gabor Marth; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Acute Lymphoblastic Leukemia (ALL) is the most common cancer in children, with close to 200 cases per year in the Nordic countries. Despite recent advances in modern chemotherapies, 20% of the ALL patients experience a relapse. LÄS MER