Sökning: "Somfai Peter"

Visar resultat 6 - 10 av 10 avhandlingar innehållade orden Somfai Peter.

  1. 6. Stereoselective Nucleophilic Additions to α-Amino Aldehydes: Application to Natural Product Synthesis

    Författare :Per Restorp; Peter Somfai; Timothy J. Donohoe; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Stereoselective synthesis; Substrate-control; α-Amino aldehydes; Mukaiyama aldol; Allylsilanes; [3 2]-Annulation; -Alexine; DGDP; Vinyl epoxides; Regioselectivity; Alkyne nucleophiles; Organic chemistry; Organisk kemi;

    Sammanfattning : This thesis deals with the development and application of new synthetic methodology for stereo- or regioselective construction of carbon-carbon bonds in organic synthesis. The first part of this thesis describes the development of a divergent protocol for stereoselective synthesis of chiral aminodiols by employing Mukaiyama aldol additions to syn- and anti-α-amino-β-silyloxy aldehydes. LÄS MER

  3. 7. New Methods for the Synthesis of Vicinal Stereocenters : Palladium-Catalyzed Domino Reactions and Asymmetric Transfer Hydrogenation

    Författare :Brinton Seashore-Ludlow; Somfai Peter; Kevin Booker-Milburn; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; asymmetric synthesis; domino reactions; palladium-catalyzed reactions; oxindoles; amino alcohols;

    Sammanfattning : In this thesis the synthesis of vicinal stereocenters is investigated in two distinct contexts, namely the construction of 3,3-disubstituted oxindoles and the synthesis of b-hydroxy-a-amino acids. Both scaffolds are prevalent in a range of natural products and biologically relevant compounds and, therefore, methods for their synthesis are of great import. LÄS MER

  4. 8. Amino Aacohols : stereoselective synthesis and applications in diversity-oriented synthesis

    Författare :Staffan Torssell; Peter Somfai; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; amino alcohol; carbenoid; carbonyl ylide; cross-metathesis; diastereoselective; 1; 3-dipolar cycloaddition; sphingosine; Organisk kemi; Organic chemistry; Organisk kemi;

    Sammanfattning : This thesis is divided into three separate parts with amino alcohols as the common feature. The first part describes the development of a novel three-component approach to the synthesis of α-hydroxy-β-amino esters. LÄS MER

  5. 9. Stereoselective Synthesis of Amino Alcohols : Applications to Natural Product Synthesis

    Författare :Staffan Torssell; Peter Somfai; Pher G Andersson; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Amino alcohol; asymmetric 1.3-dipolar cycloaddition; azomethine ylide; carbenoid; carbonyl ylide; cross-metathesis; omuralide; oxazolidine; rhodium; sphingosine; stemoamide; stereoselective synthesis; total synthesis.; Organic chemistry; Organisk kemi;

    Sammanfattning : This thesis is divided into four separate parts with amino alcohols as the common feature. The first part of the thesis describes the development of an efficient three-component approach to the synthesis of α-hydroxy-β-amino esters. LÄS MER

  7. 10. Development of New Methodology in Organic Synthesis: Lewis Acid-Mediated Rearrangements of Ammonium Ylides and Addition of 1, 3-bis(silyl) propenes to Aldehydes

    Författare :Pavel Tuzina; Peter Somfai; Ari Koskinen; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; asymmetric; amino acid; ammonium ylide; Lewis acid; microwave irradiation; Organic synthesis; Organisk syntes;

    Sammanfattning : This thesis deals with the development of new methodologies in organicsynthesis. The main focus is on the development of Lewis acid-mediated [1,2]-rearrangements of ammonium ylides and the novel addition of 1,3-bis(silyl)propenes to carbonyl compounds. LÄS MER