Sökning: "stereoselective synthesis"
Visar resultat 1 - 5 av 63 avhandlingar innehållade orden stereoselective synthesis.
1. Stereoselective Synthesis of Amino Alcohols : Applications to Natural Product Synthesis
Sammanfattning : This thesis is divided into four separate parts with amino alcohols as the common feature. The first part of the thesis describes the development of an efficient three-component approach to the synthesis of α-hydroxy-β-amino esters. LÄS MER
2. Asymmetric Synthesis of C-Glycosylated Amino Acids : Incorporation in Collagen Glycopeptides and Evaluation in a Model for Rheumatoid Arthritis
Sammanfattning : This thesis describes stereoselective syntheses of four amino acids, three of which are C-glycosidic analogues of glycosylated amino acids. The overall goal of the project was to probe the interactions between MHC molecules, glycopeptide antigens and T cell receptors, that are essential for development of collagen induced arthritis. LÄS MER
3. Methods for Asymmetric Olefination Reactions; Development and Application to Natural Product Synthesis
Sammanfattning : This thesis deals with the development and application of methods for asymmetric olefinations, in particular Horner-Wadsworth-Emmons (HWE) reactions, in the synthesis of certain natural products. Relying on asymmetric HWE reactions to access key building blocks, two natu-ral products, pyranicin and pyragonicin, were synthesized from common late intermediates. LÄS MER
4. Synthesis of Novel Polyhydroxyl Surfactants. Influence of the Relative Stereochemistry on Surfactant Properties
Sammanfattning : This thesis deals with the synthesis and characterization ofnovel polyhydroxyl surfactants. The first part describes thesynthesis of a number of stereoisomers of a polyhydroxylsurfactant, and the second part concerns surface chemicalcharacterization. LÄS MER
5. Synthesis and Studies of NADH Models: Stereoselective Reductions and Host-Guest Properties
Sammanfattning : The aim of the project has been to synthesise macrocyclic NADH models and to study them as reducing agents and hosts. Three types of macrocyclic NADH models have been synthesised. They consist of the same subunits; a chiral unit, a nicotinamide unit and an aromatic spacer. LÄS MER