Sökning: "Vinyl epoxides"

Hittade 4 avhandlingar innehållade orden Vinyl epoxides.

  1. 1. Stereoselective Nucleophilic Additions to α-Amino Aldehydes: Application to Natural Product Synthesis

    Författare :Per Restorp; Peter Somfai; Timothy J. Donohoe; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Stereoselective synthesis; Substrate-control; α-Amino aldehydes; Mukaiyama aldol; Allylsilanes; [3 2]-Annulation; -Alexine; DGDP; Vinyl epoxides; Regioselectivity; Alkyne nucleophiles; Organic chemistry; Organisk kemi;

    Sammanfattning : This thesis deals with the development and application of new synthetic methodology for stereo- or regioselective construction of carbon-carbon bonds in organic synthesis. The first part of this thesis describes the development of a divergent protocol for stereoselective synthesis of chiral aminodiols by employing Mukaiyama aldol additions to syn- and anti-α-amino-β-silyloxy aldehydes. LÄS MER

  3. 2. Design and stereoselective syntheses of Phe-Phe dipeptidomimetics

    Författare :Annika Jenmalm Jensen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Organic Pharmaceutical Chemistry; organisk farmaceutisk kemi;

    Sammanfattning : Several stereochemically well characterized Phe-Phe dipeptidomimetics have been designed and synthesized. The Phe-Phe vinyl isostere was used as a key intermediate. The synthesized series of mimetics includes two isomeric epoxides, four 1,2-dihydroxyethylene isomers, two isomeric allylic alcohols and two isomeric allylic fluorides. LÄS MER

  4. 3. Fine-tuning of the catalytic activity and selectivity of palladium pincer complexes

    Författare :Juhanes Aydin; Stockholms universitet; []
    Nyckelord :;

    Sammanfattning : This thesis is focused on optimization of the catalytic properties of so-called pincer complexes. This work involved synthesis of a large variety of palladium pincer complexes, which were applied in various organic transformations. LÄS MER

  5. 4. Novel Pincer Complex-Catalyzed Transformations : Including Asymmetric Catalysis

    Författare :Juhanes Aydin; Kálmán J. Szabó; Oleg V. Ozerov; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; pincer; palladium; catalysis; chiral; asymmetric; palladium IV; allylation; aldol; aminoacid; C-H functionalization; cross-coupling; homoallylic; heck reaction; tridentate ligand; Chemistry; Kemi; Organic Chemistry; organisk kemi;

    Sammanfattning : This thesis is focused on the development of new pincer complex-catalyzed transformations. Optimization of the catalytic properties (fine-tuning) was directed to increase the catalytic activity as well as the chemo-, stereo- and enantioselectivity of the complexes. LÄS MER