Sökning: "azomethine ylide"

Hittade 4 avhandlingar innehållade orden azomethine ylide.

  1. 1. Stereoselective Synthesis of Amino Alcohols : Applications to Natural Product Synthesis

    Författare :Staffan Torssell; Peter Somfai; Pher G Andersson; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Amino alcohol; asymmetric 1.3-dipolar cycloaddition; azomethine ylide; carbenoid; carbonyl ylide; cross-metathesis; omuralide; oxazolidine; rhodium; sphingosine; stemoamide; stereoselective synthesis; total synthesis.; Organic chemistry; Organisk kemi;

    Sammanfattning : This thesis is divided into four separate parts with amino alcohols as the common feature. The first part of the thesis describes the development of an efficient three-component approach to the synthesis of α-hydroxy-β-amino esters. LÄS MER

  3. 2. Synthesis of Nitrogen Heterocycles via 1,3-Dipolar Cycloadditions - Method Development and Applications

    Författare :Johan Johansson; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; 2D NOESY; alkyne; 3-dipolar cycloaddition; azomethine ylide; 1; CNTs; azide; sequential one-pot; SEM EDS; microwave heating; RuAAC; CuAAC;

    Sammanfattning : Because of the diverse properties displayed by nitrogen heterocycles, they are one of the most commonly used structural elements in drug discovery. Due to this variation in properties, however, the chemistry and synthetic pathway to each heterocycle is unique. LÄS MER

  4. 3. Natural Product Synthesis and Development of Novel Reaction Methodology

    Författare :Jakob Danielsson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; perophoramidine; communesin; quaternary stereocenter; Diels-Alder; 1; 2-asymmetric induction; polar Felkin-Anh; Cornforth-Evans; Mukaiyama aldol; 3-dipolar cycloaddition; azomethine ylide; 2-amino alcohol; anti-α-amino-β-hydroxy ester;

    Sammanfattning : This thesis deals with the development of new reaction methodology for stereoselective synthesis, as well as total synthesis of natural products and investigations of the stereochemical outcome in the Mukaiyama aldol reaction. Chapter 2 describes efforts made towards the total synthesis of the oxindole natural products perophoramidine and the communesin. LÄS MER

  5. 4. Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties

    Författare :Stanley Rehn; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Isatin; three-component reaction; a-amino acid; azomethine ylide; pyrrolidino-3-spiro-3?-oxindole derivatives; 3-methyleneoxindole derivatives; pyrroloquinolone; TosMIC; ß-carboline; tosylimine; pyrrole; keto-enol tautomerism; indolopyran-2-one; imidazole; benzylimine; tetrahydroindole;

    Sammanfattning : The focus of this thesis is on the synthesis of oxindole- and indole-derivatives incorporating pyrrolidins, pyrroles or imidazoles moieties. Pyrrolidino-2-spiro-3'-oxindole derivatives have been prepared in high yielding three-component reactions between isatin, alpha-amino acid derivatives, and suitable dipolarophiles. LÄS MER