Sökning: "Septic shock"

Visar resultat 6 - 10 av 73 avhandlingar innehållade orden Septic shock.

1. 6. Modulating Organ Dysfunction in Experimental Septic Shock : Effects of Aminoglycosides, Antiendotoxin Measures and Endotoxin Tolerance

   Författare :Markus Castegren; Jan Sjölin; Claes Frostell; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lipopolysaccharide; animal model; pig; tobramycin; endotoxin elimination; immunoparalysis; secondary sepsis; Infectious diseases; Infektionssjukdomar; Infektionssjukdomar; Infectious Diseases;

   Sammanfattning : Sepsis is a common diagnose in the intensive care population, burdened with a high mortality. The systemic inflammatory reaction underlying the development of septic organ dysfunction can be modeled using Gram-negative bacterial lipopolysaccharide, endotoxin. LÄS MER

3. 7. Antibacterial Effect and Inflammatory Response in Relation to Antibiotic Treatment of Sepsis

   Författare :Paul Skorup; Jan Sjölin; Miklós Lipcsey; Kristoffer Strålin; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Sepsis; Septic shock; Antibiotics; Aminoglycoside; β-lactam; Bacteria; E. coli; Inflammation; Cytokines; Endotoxin; Porcine; ICU; Secondary sepsis; Endotoxin-tolerance.; Infektionssjukdomar; Infectious Diseases;

   Sammanfattning : Sepsis defines as life-threatening organ dysfunction caused by a dysregulated host response to infection. The importance of early administration of antibiotics in septic shock is undisputed, but the optimal antibiotic choice remains uncertain. LÄS MER

4. 8. Integrin αVβ3-Directed Contraction by Connective Tissue Cells : Role in Control of Interstitial Fluid Pressure and Modulation by Bacterial Proteins

   Författare :Åsa Lidén; Kristofer Rubin; Karl-Eric Magnusson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; interstitial fluid pressure; collagen gel contraction; integrin αVβ3; septic shock; fibronectin; Biokemi; Biochemistry; Biokemi;

   Sammanfattning : This thesis aimed at studying mechanisms involved in control of tissue fluid homeostasis during inflammation.The interstitial fluid pressure (PIF) is of importance for control of tissue fluid balance. A lowering of PIF in vivo will result in a transport of fluid from the circulation into the tissue, leading to edema. LÄS MER

5. 9. Levosimendan in early experimental sepsis: effects on the heart and hepatosplanchnic circulation

   Författare :Doris Cunha Goncalves; Anestesiologi och intensivvård; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; septic shock; myocardial oxygen consumption; myocardial dysfunction; levosimendan; endotoxin; contractility; catecholamines; calcium sensitizer; cardiotonic agents; splanchnic perfusion;

   Sammanfattning : Sepsis-related cardiovascular dysfunction associated with fluid-unresponsive tissue hypoperfusion might require inotropic treatment. This cardiovascular dysfunction seems to involve calcium desensitization and adrenergic unresponsiveness. LÄS MER

7. 10. Mitochondrial function in sepsis - Temporal evolvement of respiratory capacity in human blood cells

   Författare :Fredrik Sjövall; Lund Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human; sepsis; severe sepsis; septic shock; platelets; mitochondria; OXPHOS; high-resolution respirometry; mitochondrial disorders; multiple organ failure; biogenesis; leukocytes; cytokines; respirometry; oxygen consumption; blood cells; temporal;

   Sammanfattning : Sepsis is a devastating disease that is caused by the host’s response to an overwhelming infectious process. As sepsis progresses, organs distant from the site of infection become affected and sepsis-induced multiple organ failure ensues. LÄS MER