Sökning: "SH-SY5Y"
Visar resultat 16 - 20 av 55 avhandlingar innehållade ordet SH-SY5Y.
16. Polyamine analogues inhibit neuroblastoma cell growth
Sammanfattning : Abstract Neuroblastoma is a highly malignant neoplasm found in children. Although children with high-risk neuroblastoma respond to chemotherapy, relapses are common and an estimated long-time survival prognosis is approximately 15%. Thus, there is a tremendous need for new chemotherapeutic drugs for the treatment for neuroblastoma. LÄS MER
17. Regulation of apoptotic processes in neurodegeneration and cancer : In vitro studies on human neuroblastoma cells
Sammanfattning : Apoptosis is a highly controlled process of cell death, which is vital for maintenance of all multicellular organisms. Aberrant regulation of apoptosis can give rise to pathological conditions such as neurodegenerative diseases and cancer. LÄS MER
18. Age dependent beta-amyloid isoforms and implications of different drug treatments as studied in different transgenic mouse models and cell lines
Sammanfattning : The Amyloid-β (Aβ) peptide is the main component of the the amyloid plaques in Alzheimer’s Disease (AD) and has been implicated to be the cause of the disease. During the last decade it has become increasingly evident that soluble, oligomeric forms of Aβ are more toxic to neurons than the plaques and might play an important role in the disease pathogenesis. LÄS MER
19. Cell death and signal transduction pathways in Alzheimer's disease : the role of presenilin 1
Sammanfattning : Mutated presenilins (PSs) may cause familial Alzheimer's disease (FAD) by altering neuronal signal transduction pathways, by increasing AP production or by triggering a number of proapoptotic mechanisms. The present thesis explores mechanisms by which PSs regulate signal transduction and cell death with relevance to AD. LÄS MER
20. Investigation on Pre- and Postsynaptic Ca2+ Signaling in Neuronal Model Systems
Sammanfattning : Communication between neuronal and non-neuronal is called volume transmission when the released neurotransmitter (NT) acts via diffusion and affects several target cells. Both the neurosecretory and postsynaptic cell responses are linked to [Ca2+]i elevations. LÄS MER