Sökning: "polyamine analogue"

Hittade 5 avhandlingar innehållade orden polyamine analogue.

  1. 1. Polyamine analogues inhibit neuroblastoma cell growth

    Författare :Erika Söderstjerna; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; survivin; cell cycle; polyamine analogue; polyamines; apoptosis; neuroblastoma; MYCN;

    Sammanfattning : Abstract Neuroblastoma is a highly malignant neoplasm found in children. Although children with high-risk neuroblastoma respond to chemotherapy, relapses are common and an estimated long-time survival prognosis is approximately 15%. Thus, there is a tremendous need for new chemotherapeutic drugs for the treatment for neuroblastoma. LÄS MER

  3. 2. Regulation of Polyamine Analogue-Induced Apoptosis in Human Breast Cancer Cells

    Författare :Martina Holst; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cancer; Animal physiology; Djurfysiologi; Pharmacological sciences; pharmacognosy; pharmacy; onkologi; Cytologi; cancerology; oncology; Cytochrome c; Cytology; Bcl-2; Mitochondrial respiration; Apoptosis; Human breast cancer cells; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi; Social medicine; Socialmedicin; samhällsmedicin; Mitochondria; Polyamine analogues;

    Sammanfattning : Apoptosis is a defined process for cells to commit suicide through a set of biochemical and morphological cell changes. Activated apoptotic signals converge on the mitochondria, leading to permeabilization of mitochondrial membranes and release of different apoptosis regulatory proteins into the cytosol. LÄS MER

  4. 3. Markers predicting sensitivity to polyamine depletion in human breast cancer cell lines

    Författare :Veronica Johansson; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PCNA; PAO; human breast cancer cell lines; FEN1; DNA strand breaks; DNA ligase I; apoptosis; Bcl-2; polyamine analogues; pRb;

    Sammanfattning : In spite of different treatment strategies today, breast cancer mortality is still high and new treatments are therefore needed. Potential new treatments can be found among the polyamine analogues. Polyamine analogues can be used in cancer treatment as cancer cells have a higher requirement for polyamines than the surrounding healthy tissue. LÄS MER

  5. 4. Effects of polyamine pool manipulation on genes expressed during the cell cycle

    Författare :Pia Berntsson; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Animal physiology; cyclin A; ODC; MCF-7; mitotic shake off; DENSPM; CHO; cDNA microarray; cell cycle; spermine; Djurfysiologi; AdoMetDC; 2D gel electrophoresis; polyamines; spermidine; putrescine;

    Sammanfattning : The polyamines - putrescine, spermidine and spermine - are polycations found within cells. They have been shown to be essential for optimal cell proliferation and cell survival. Cells maintain their polyamine levels in a well-regulated system involving biosynthesis, catabolism and uptake/excretion. LÄS MER

  7. 5. On the Role of Polyamines in Apoptosis

    Författare :Cecilia Hegardt; Bröstcancer-genetik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; SSAT; DENSPM; spermine; polyamines; mitochondrial membrane potential; cytochrome c; caspase; flow cytometry; Jurkat cells; mouse thymocytes; thymus in vivo; programmed cell death; Dexamethasone-induced apoptosis; Fas-induced apoptosis; AdoMetDC; Cytology; oncology; cancerology; Cytologi; onkologi; cancer; Clinical biology; Klinisk biologi; Animal physiology; Djurfysiologi;

    Sammanfattning : Apoptosis is a kind of death that is best described as cellular suicide and it is important for normal tissue homeostasis. The process can be induced by a number of different stimuli and the dying cell goes through a defined pathway terminating in typical biochemical and morphological alterations of the cell. LÄS MER