Sökning: "Regulatory Toxicology"

Visar resultat 1 - 5 av 32 avhandlingar innehållade orden Regulatory Toxicology.

1. 1. Management of chemical risk through occupational exposure limits

   Författare :Linda Schenk; Christina Rudén; Michael Gilek; Maria Albin; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; occupational exposure limit; risk assessment; risk management; chemicals regulation; regulatory toxicology; European Union; Toxicology; Toxikologi;

   Sammanfattning : Occupational Exposure Limits (OELs) are used as an important regulatory instrument to protect workers’ health from adverse effects of chemical exposures. The OELs mirror the outcome of the risk assessment and risk management performed by the standard setting actor. LÄS MER

3. 2. Setting occupational exposure limits : Practices and outcomes of toxicological risk assessment

   Författare :Linda Schenk; Christina Rudén; Alan Boobis; Michael Gilek; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Assessment Factor; DNEL; Euroepan Union; Occupational Exposure Limit; REACH; Risk Assessment; Regulatory Toxicology; SCOEL; Uncertainty Factor; Toxicology; Toxikologi;

   Sammanfattning : Occupational Exposure Limits (OELs) are used as an important regulatory instrument to protect workers’ health from adverse effects of chemical exposures. The main objective of this thesis is to study risk assessment practices in the setting of OEL in order to produce knowledge that will help improve the consistency and transparency of OELs. LÄS MER

4. 3. Mechanisms behind Cadmium-Induced Teratogenicity

   Författare :Estíbaliz López Fernández de Villaverde; Lennart Dencker; Ulf Eriksson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Cadmium; Teratogenesis; Exencephaly; Mechanisms; Toxikologi; Toxicology; Toxikologi;

   Sammanfattning : Heavy metals polluting our environment cause concern for developing organisms. Among them, cadmium with extremely slow elimination from the body, causes lower birth weight in humans but has not been classify as a human teratogen. Studies in different laboratory animals have shown that cadmium indeed is a potent teratogen. LÄS MER

5. 4. Proteomic Characterization of Induced Developmental Neurotoxicity

   Författare :Henrik Alm; Lennart Dencker; R Stuart Cobb; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proteomics; Brain Development; Neurotoxicity; 2D-DIGE; Brain Growth Spurt; Polybrominated Diphenyl Ether; Neonatal; Striatum; Hippocampus; Cerebral Cortex; Parkinsonism; Dyskinesia; Toxicology; Toxikologi; Toxicology; Toxikologi;

   Sammanfattning : The developing brain goes through a number of developmental periods during which it displays an increased sensitivity to exogenous disturbances. On such period is the so called “Brain growth spurt” (BGS) which in humans takes place starting from the third trimester of pregnancy and throughout the first few years of life. LÄS MER

7. 5. Regulatory tools for managing chemicals risk at the workplace

   Författare :Qian Ding; Sven Ove Hansson; Maria Albin; KTH; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Occupational Diseases; Chemicals; Carcinogens; Risk Management; Regulatory Toxicology; Occupational Exposure Limits; Chemicals Legislations; Risk Assessment; Acceptable Risk;

   Sammanfattning : This thesis focuses on exacerbating chemicals risk in workplaces under the background of rapid industrialization in developing countries. The overall aim is to investigate the development of regulatory tools which aim at minimizing the health risks from chemical substances in the workplace. LÄS MER