Sökning: "R-package"

Visar resultat 11 - 15 av 25 avhandlingar innehållade ordet R-package.

  1. 11. Little strokes fell great oaks : small RNA in potato and Phytophthora infestans interactions

    Författare :Kristian Persson Hodén; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : Small RNAs (sRNAs) are non-coding RNAs of approximately 20-30 nucleotides in length. sRNAs bind to Argonaute proteins (AGOs) an integrated partner of the RISC complex. sRNAs act as templates for RISC to recognize complementary mRNA transcripts which can be cleaved by AGOs and thereby cause gene inactivity. LÄS MER

  3. 12. Mapping Transcriptomes in Tissues

    Författare :Ludvig Larsson; Joakim Lundeberg; Stefania Giacomello; Naveed Ishaque; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; spatially resolved transcriptomics; spatial transcriptomics; transcriptomics; data analysis; rumsligt upplöst transkriptomik; rumslig transkriptomik; transkriptomik; dataanalys; Biotechnology; Bioteknologi;

    Sammanfattning : Over the past few decades, the advent of pioneering biotechnological methods has allowed scientists to analyze the molecular components of multicellular organisms with remarkable precision. The field of transcriptomics has witnessed a rapid development of technologies for gene expression profiling of biological samples. LÄS MER

  4. 13. Uncovering biomarkers and molecular heterogeneity of complex diseases : Utilizing the power of Data Science

    Författare :Sara Younes; Linda Holmfeldt; Jan Komoroski; Aedin Culhane; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Complex Disease; Cancer; Autoimmune diseases; Acute Myeloid Leukemia; Systemic Lupus Erythematosus; Bioinformatics; Machine Learning; Data Science; Statistical Analysis; Bioinformatics; Bioinformatik; Computer Science; Datavetenskap;

    Sammanfattning : Uncovering causal drivers of complex diseases is yet a difficult challenge. Unlike single-gene disorders complex diseases are heterogeneous and are caused by a combination of genetic, environmental, and lifestyle factors which complicates the identification of patient subgroups and the disease causal drivers. LÄS MER

  5. 14. Statistical methods for biomarker discovery in proteomics

    Författare :Chuen Seng Tan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Proteomics; mass spectrometry; SELDI; MALDI; peak detection; signal detection; peak annotation; transcriptomics; data integration; maximum covariance analysis; generalized singular value decomposition;

    Sammanfattning : Surface-Enhanced Laser Desorption and Ionization (SELDI) is a promising proteomic technique for discovering biomarkers. However, the pre-processing of the raw data is still problematic. LÄS MER

  7. 15. The role of epigenetics in multiple sclerosis development, progression and treatment

    Författare :Ewoud Ewing; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The overall aim of this thesis was to determine epigenetic changes in peripheral immune cells from Multiple Sclerosis (MS) patients. MS is a chronic inflammatory neurodegenerative disease, which initially presents itself during young adulthood. LÄS MER