Sökning: "Quantitative Trait Locus"

Visar resultat 6 - 10 av 36 avhandlingar innehållade orden Quantitative Trait Locus.

  1. 6. Type 2 Diabetes Genes Contributing to Insulin Secretion Defects

    Författare :Charlotte Granhall; Genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sekretion; Endokrinologi; exocytosis; GK rat; NIDDM1I; genetics; gene expression; quantitative trait analysis; Sorcs1; Adra2a; Endocrinology; diabetology; insulin secretion; diabetologi; secreting systems; Type 2 diabetes;

    Sammanfattning : Type 2 diabetes is caused by a combination of environmental and inherited factors influencing the progression of insulin resistance and impaired insulin secretion leading to chronically elevated blood glucose levels. The aim of this thesis was to functionally and genetically characterise the species-conserved diabetes locus Niddm1i of the GK rat encoding hyperglycaemia and defect insulin secretion. LÄS MER

  3. 7. Evolutionary dynamics of migration and breeding in wild birds: genetic architecture, sexual conflicts and evolutionary constraints

    Författare :Maja Tarka; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; quantitative genetics; heritability; intralocus sexual conflict; antagonistic selection; QTL; G-matrix; wing length; arrival date; migration; geolocator; bird; Acrocephalus arundinaceus;

    Sammanfattning : Our knowledge of the evolutionary potential of traits involved in different selective episodes, especially in natural populations, is still limited. This is true for questions such as the genetic basis and inheritance of traits, how natural and sexual selection acts on them, and how selective conflicts influence the evolutionary response to selection. LÄS MER

  4. 8. Quantitative genetics of gene expression and methylation in the chicken

    Författare :Andrey Höglund; Dominic Wright; Per Jensen; Rie Henriksen; Kees van Oers; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : In quantitative genetics the relationship between genetic and phenotypic variation is investigated. The identification of these variants can bring improvements to selective breeding, allow for transgenic techniques to be applied in agricultural settings and assess the risk of polygenic diseases. LÄS MER

  5. 9. Identification and characterization of DNA sequence variants associated with multiple myeloma

    Författare :Mina Ali; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :Multiple myeloma; inherited susceptibility; genome-wide association study; ELL2; expression quantitative trait loci;

    Sammanfattning : Multiple myeloma (MM) is the second most common hematologic malignancy. The disease is characterized by an uncontrolled growth of malignant plasma cells in the bone marrow, producing a monoclonal immunoglobulin (“M protein”) that can be detected in peripheral blood. LÄS MER

  7. 10. FAM167A-BLK is a susceptibility locus in autoimmune diseases : characterization of the FAM167 gene family

    Författare :Lara Mentlein; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autoimmune diseases are complex multifactorial diseases, and their pathogenesis is only partially understood, but both genetic, as well as environmental factors, have been correlated to an increased risk for the diseases. Genome-wide association studies of Sjögren’s syndrome, systemic lupus erythematosus, and rheumatoid arthritis have identified many risk loci; most studies include associations to the FAM167A-BLK locus. LÄS MER