Sökning: "Quantitative Trait Locus"
Visar resultat 11 - 15 av 36 avhandlingar innehållade orden Quantitative Trait Locus.
11. Immunologic and genetic studies of rat adjuvant-induced arthritis
Sammanfattning : Rheumatoid arthritis (RA) is a chronic inflammatory joint disease with a multifactorial and largely unknown etiology. It is influenced by both environmental and genetic factors, and understanding of disease mechanisms and identification of disease-causing genes is hampered by the complex and polygenic nature of the disease. LÄS MER
12. Genetic factors influencing susceptibility to intracellular infections
Sammanfattning : Genetics of susceptibility to infection is a complex trait in which many factors from the host, the parasite and the environment, interact to produce different clinical manifestations of disease. This thesis explores the relationship between the first infectious susceptibility gene ever cloned, SLC11A1 and the occurrence of intracellular infections (leprosy, leishmaniasis and HIV infection) in several populations of humans. LÄS MER
13. Genetic dissection of multifactorial disease models in the rat
Sammanfattning : Type 2 diabetes (T2D) is characterized by two apparently distinct pathophysiologic defects - insulin resistance and a failure of the pancreatic Beta-cells to compensate for this resistance by appropriately increasing insulin secretion. There is strong evidence for an important role of genetics in both of these components. LÄS MER
14. Molecular genetics of type 2 diabetes
Sammanfattning : Type 2 diabetes is a common and chronic disease caused by interactions between genetic and environmental factors. The Goto-Kakizaki (GK) rat is a well-established genetic model of type 2 diabetes. LÄS MER
15. Genomics of chicken domestication and feralisation
Sammanfattning : Domestication can serve as a study system of rapid evolutionary change with wide-ranging effects on traits in animals. The chicken was domesticated from the Red Junglefowl and has diverged in behaviour, morphology and life history traits. LÄS MER