Sökning: "Genetic susceptibility"

Visar resultat 1 - 5 av 498 avhandlingar innehållade orden Genetic susceptibility.

  1. 1. Genetic susceptibility to cervical and gastric cancer

    Författare :Patrik Magnusson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; cervical cancer; gastric cancer; genetic susceptibility; familiality; heritability; HPV; Helicobacter pylori; genetic association; HLA; P53; loss of heterozygosity; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Sammanfattning : Cervical and gastric cancer both to a large extent depend on infectious agents. Cervical infection with human papilloma virus increases the risk for cervical cancer substantially, and infection with the bacteria Helicobacter pylori increases the risk for gastric cancer. LÄS MER

  3. 2. Susceptibility genes in conformational diseases

    Författare :Malin von Otter; Göteborgs universitet; []
    Nyckelord :Conformational disease; Alzheimer’s disease; Parkinson’s disease; Cataract Protein aggregation; Cellular transport; Oxidative stress; Susceptibility; genes; SNP; Haplotype;

    Sammanfattning : Conformational diseases are characterized by protein misfolding and aggregation in the affected tissue. The aim of this thesis was to find genetic support for mechanisms in common for three prevalent ... LÄS MER

  4. 3. Susceptibility to chronic liver disease

    Författare :Maria Antonella Burza; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chronic liver disease; susceptibility; human genetics; NAFLD; ALD; PNPLA3;

    Sammanfattning : The onset and the progression of chronic liver disease involve environmental and genetic factors. Hepatic stellate cells (HSCs) are important players in these processes and are the main storage site for retinol. LÄS MER

  5. 4. Obesity and Increased Susceptibility : Role of FTO and MGAT1 Genetic Variants

    Författare :Josefin A Jacobsson; Robert Fredriksson; Helgi B Schiöth; Sadaf Farooqi; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Obesity; BMI; SNP; haplotype; association study; FTO; MGAT1; Pharmacology; Farmakologi; Farmakologi; Pharmacology;

    Sammanfattning : Obesity is a complex and a highly individualized disease and the molecular mechanisms behind this disorder need to be better elucidated. Identification of genes and genetic variants that are involved provide opportunities to establish a genetic understanding of the disease. LÄS MER

  7. 5. On the aetiology of ALS : a comprehensive genetic study

    Författare :Caroline Ingre; Peter M Andersen; Rayomand Press; Siddharthan Chandran; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; risk factor; VAPB; SOD1; amyotrophic lateral sclerosis; ATXN2; SMN1; SMN2; PFN1; 50 bp deletion in SOD1 promotor; population-specific genetic variations; Neurology; neurologi;

    Sammanfattning : Introduction: Amyotrophic lateral sclerosis (ALS) is a deadly, progressive neuromuscular disease that affects individuals all over the world. About 10% of the patients have a familial predisposition (FALS) while the remainder of cases are isolated or sporadic (SALS) and of unknown cause. LÄS MER