Sökning: "HIV-1 genetic subtypes"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden HIV-1 genetic subtypes.

  1. 1. HIV-1 infection of the central nervous system. Markers of pathogenesis and antiretroviral treatment effects

    Författare :Sahra Abdulle; Göteborgs universitet; []
    Nyckelord :HIV-1; cerebrospinal fluid; antiretroviral therapy; neopterin; beta2-microglobulin; CSF HIV-1 RNA; blood-brain barrier; IgG index; HIV-related neurological diseases; AIDS Dementia Complex; neurofilament protein; HIV-1 genetic subtypes;

    Sammanfattning : Human immunodeficiency virus type 1 (HIV-1) invades the central nervous system (CNS) early in the course of infection and either directly or through opportunistic infections causes a spectrum of neurological complications. The most severe manifestation of HIV-1 CNS infection is AIDS Dementia Complex (ADC), which occurs in approximately 20% of untreated patients with AIDS. LÄS MER

  3. 2. Significance of HIV-1 genetic subtypes

    Författare :Annette Alaeus; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1; genetic subtypes; molecular epidemiology; disease progression; CD4 cell decline; plasma RNA levels; chemokine coreceptor usage;

    Sammanfattning : The human immunodeficiency virus type 1 (HIV-1) displays high genetic variability. Phylogenetic studies have shown that a majority of HIV-1 sequences cluster into one large group called M (major), whereas a few are clearly distinct, group O (outlier) and group N (non-M-non-O). LÄS MER

  4. 3. Genetic aspects of HIV-1 evolution and transmission

    Författare :Irina Maljkovic Berry; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : HIV-1 is one of the fastest evolving organisms known to man. Its rate of evolution is approximately one million times faster than that of higher organisms such as ourselves, meaning that the amount of changes within the HIV-1 genome in just one year corresponds to the amount of changes within the human genome in one million years. LÄS MER

  5. 4. Genetic dynamics of HIV-1 : recombination, drug resistance and intrahost evolution

    Författare :Karin Wilbe; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1; genetic evolution; recombination; drug resistance; intrahost evolution;

    Sammanfattning : A striking characteristic of HIV is the enormous capacity of genetic variation. Frequent mutations, deletions, insertions and recombination events create a population of genetically related but non-identical viruses that is under constant change and ready to adapt to environmental changes. LÄS MER

  7. 5. Genetic variation of HIV-1 : molecular epidemiology and viral evolution

    Författare :Thomas Leitner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : HIV-1 displays a very high genetic variability. The evolutionary process of the virus generates a nucleotide substitution rate which is approximately one million times faster than that of higher organisms. This remarkable rate in combination with a half-life of six to eight hours, gives HIV-1 an enormous potential of genetic adaptation. LÄS MER