Sökning: "leishmaniasis"

Visar resultat 1 - 5 av 26 avhandlingar innehållade ordet leishmaniasis.

1. 1. Drug discovery against leishmaniasis : Bio- and chemoinformatic guided strategies for target evaluation and hit identification

   Författare :Elisabet Vikeved; UCM Alsmark; Christian Sköld; David Horn; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Leishmaniasis; Drug discovery; Lateral gene transfer; Comparative genomics; Virtual screening; Target fishing; Marine natural products;

   Sammanfattning : Leishmaniasis is a neglected tropical disease mainly affecting poor people in developing countries. It is caused by infections of flagellated protozoa belonging to genus Leishmania. The few available drugs are associated with problems such as low effectiveness, severe side effects and resistance development. LÄS MER

3. 2. Leishmaniasis in Sweden. Molecular, diagnostic and epidemiological studies of the parasite Leishmania in a non-endemic country

   Författare :Sara Karlsson Söbirk; Infektionsmedicin; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; leishmaniasis; Parasite; Epidemiological studies; Serology; diagnostic method; Immune System; Sweden; leishmaniasis; Leishmania; immune system; chitinase; CAZy; Immune evasion; Antimicrobial peptide AMP ; Chemokine; epidemiology; Sweden; Serological assays; diagnostic method;

   Sammanfattning : This doctoral thesis consists of four separate papers, in which we; investigate epidemiological and clinical aspects of leishmaniasis in Sweden in order to increase awareness of the disease, elucidate some aspects of the interaction of the parasite and the human immune system and validate serological tools as a complement for diagnosis of leishmaniasis.. LÄS MER

4. 3. The Role of Zinc in Leishmaniasis and Tuberculosis

   Författare :Miguel Guzman; Tillämpad biokemi; []
   Nyckelord :Cutaneous leishmaniasis; tuberculosis; zinc supplementation; lymphocytes; cell proliferation; INF-γ; CD4 CD8 ratio;

   Sammanfattning : The synergistic relation between nutritional deficiency and infection may have negative effects on the immune system, making individuals more vulnerable to infection. Zinc can affect the resistance to infections by modulating cytokine release, and by acting as a cofactor of thymulin, which induces the differentiation of immature T lymphocytes. LÄS MER

5. 4. The rough journey to access health care : the case of leishmaniasis in the Bolivian rainforest

   Författare :Daniel V. Eid Rodríguez; Miguel San Sebastián; Isabel Goicolea; Anna-Karin Hurtig; John Porter; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cutaneous leishmaniasis; Health-care access; risk factors; population surveillance; capture-recapture; health care seeking behavior; intralesional pentavalent antimonials; economic analysis; cost analysis; budget impact analysis; Bolivia; rainforest; Public health; folkhälsa;

   Sammanfattning : Background: Leishmaniasis is a parasitic infectious disease transmitted by vectors that cause three main clinical syndromes: cutaneous (CL), mucosal (ML), and visceral (VL). Since VL is not relevant to this thesis, only CL and ML will be further discussed. LÄS MER

7. 5. Bioactive leishmanicidal alkaloid molecules from Galipea longiflora Krause with immunomodulatory activity

   Författare :Jacqueline Calla-Magariños; Carmen Fernández; Marita Troye-Blomberg; Geneviève Milon; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Leishmania infection; Leishmaniasis; herbal medicine; natural products; Galipea longiflora Krause; Evanta; cytokines; IFN-gamma; dendritic cells; inflammation; meglumine antimoniate; immunologi; Immunology;

   Sammanfattning : According to WHO, leishmaniasis is endemic in 98 countries, and has been placed ninth in a global analysis of infectious diseases. Treatment of leishmaniasis is based on pentavalent antimonials but toxicity and developing resistance have been reported. LÄS MER