Sökning: "structural investigation"

Visar resultat 1 - 5 av 519 avhandlingar innehållade orden structural investigation.

  1. 1. Structural investigation of human mitochondrial translation and off-target antibiotic binding

    Författare :Vivek Singh; Alexey Amunts; Yaser Hashem; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mitochondrial translation; mitoribosome; electron cryo-microscopy; LRPPRC-SLIRP; antibiotics; streptomycin; Biophysics; biofysik;

    Sammanfattning : Human mitochondrial translation machinery has evolved to translate 13 mitochondrial mRNAs encoding components of the oxidative phosphorylation pathway responsible for ATP production. The structural basis of human mitochondrial translation is distinct from the canonical bacterial and cytosolic translation systems. LÄS MER

  3. 2. Structural assessment procedures for existing concrete bridges : Experiences from failure tests of the Kiruna Bridge

    Författare :Niklas Bagge; Björn Täljsten; Paulo Cruz; Luleå tekniska universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Anchorage; carbon fibre reinforced polymers; concrete; existing bridges; finite element analysis; flexure; full-scale test; load-carrying capacity; residual prestress force; punching; safety verification; shear; structural assessment; structural behaviour; Structural Engineering; Konstruktionsteknik;

    Sammanfattning : Assessing existing bridges is an important task in the sustainable management ofinfrastructure. In practice, structural bridge assessments are usually conducted usingtraditional and standardised methods, despite knowledge that these methods oftenprovide conservative estimates. LÄS MER

  4. 3. Structural and Biochemical Characterizations of Three Potential Drug Targets from Pathogens

    Författare :Lu Lu; Sherry L Mowbray; Alwyn Jones; Christian Cambillau; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LepB; DXR; NDH-2; fosmidomycin; quinolinyl pyrimidine; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

    Sammanfattning : As antibiotic resistance of various pathogens emerged globally, the need for new effective drugs with novel modes of action became urgent. In this thesis, we focus on infectious diseases, e.g. LÄS MER

  5. 4. Structural characterisation of mitochondrial macromolecular complexes using cryo-EM : Mitoribosome biogenesis and respiratory chain supercomplex

    Författare :Sorbhi Rathore; Martin Ott; Daniel Wilson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mitochondria; mitoribosome biogenesis; mitoribosome assembly factors; yeast respiratory supercomplexes; single particle electron cryo-microscopy; cryo-EM sample preparation; Biochemistry; biokemi;

    Sammanfattning : Mitochondria, popularly known as powerhouse of the cell, contain specialised mitoribosomes that synthesise essential membrane proteins. These essential proteins are required to form enzyme complexes, which carry out the process of oxidative phosphorylation (OXPHOS). LÄS MER

  7. 5. Production and investigation of highly thermophilic multi-domain carbohydrate-active enzymes

    Författare :Daniel Krska; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; protein structure; xylanase; carbohydrate esterase; multidomain enzymes; carbohydrate-active enzymes; thermostable enzymes; plant biomass degradation; Caldicellulosiruptor;

    Sammanfattning : With the looming threat of climate change caused largely by an excess of carbon dioxide in the atmosphere, recent scientific efforts have focused on the substitution of fossil fuels and other polluting compounds with more environmentally conscious choices. To this end, the investigation of biomass as both a renewable source of energy and as a chemical basis to produce high-value products is being extensively investigated. LÄS MER