Sökning: "Small heat shock protein"
Visar resultat 1 - 5 av 26 avhandlingar innehållade orden Small heat shock protein.
1. Exploring small heat shock protein chaperones by crosslinking mass spectrometry
Sammanfattning : Together with other molecular chaperones, small heat shock proteins are key components of the protein quality control system, which is comprised of several hundred proteins and acts to maintain proteome homeostasis in the cell. Small heat shock proteins bind unfolding proteins at an early stage, to prevent these from further unfolding and aggregating. LÄS MER
2. Interactions Between Small Heat Shock Proteins and Substrate Proteins Mass Spectrometric Detection of Crosslinked Peptides to Map Protein-Protein Interactions
Sammanfattning : The small heat shock proteins (sHsps) are a widespread class of molecular chaperones existing in all organisms. During heat stress the sHsps protect other proteins from unfolding and aggregation. In plants the sHsps play an especially prominent part of the stress response. LÄS MER
3. Combined structural methods to characterize an oligomeric small heat shock protein Hsp21
Sammanfattning : Small heat shock proteins (sHsps) are found in all organisms and evolved early in the history of life, prior to the divergence of the three domains of life (Archaea, Bacteria, and Eukarya). Their malfunction is connected to several different diseases in humans, such as Alzheimer’s and Parkinson’s disease. LÄS MER
4. The conserved methionines in the chloroplast small heat shock protein - Role in chaperone-substrate interactions and effects of methionine sulfoxidation on chaperone activity
Sammanfattning : The chloroplast-localized small heat shock protein (sHsp) Hsp21 belongs to the family of alpha-crystallin like sHsps which form large oligomeric structures and protect partly unfolded aggregation-prone proteins against aggregation. The main focus for this thesis has been on the highly conserved methionines in Hsp21. LÄS MER
5. Peripheral nerve function : metabolic features, clinical assessment, and heat shock protein 27
Sammanfattning : Peripheral neuropathy is a common complication among patients with diabetes mellitus, but whether peripheral neuropathy is present in individuals with impaired glucose tolerance (IGT) is debatable. In order to identify and diagnose peripheral neuropathy correctly, it is important to evaluate diagnostic tools that can be implemented in routine health care to assess both large and small nerve fibre function. LÄS MER