Sökning: "Plasmacytoid dendritic cell"

Visar resultat 21 - 25 av 34 avhandlingar innehållade orden Plasmacytoid dendritic cell.

  1. 21. Regulation of NK cell activity : studies of DAP12-associated receptors in immune synapse formation and in responses to cytomegalovirus infection

    Författare :Hanna Sjölin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NK cells; DAP12; MCMV Cytokines; Receptors; Signaling; packages;

    Sammanfattning : Natural killer (NK) cell effector functions are important for innate resistance against tumor cells and viral infections. NK cells display a broad range of inhibitory and activating receptors on the cell surface, which ensure specificity. LÄS MER

  3. 22. Regulation of human dendritic cells and T cells by adenovirus vectors types 5 and 35 : implications for vaccine design

    Författare :William C Adams; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Following viral infection or vaccination dendritic cells (DC) perform an intricate series of roles at the interface of innate and adaptive immunity. Peripheral DC recognition of pathogen associated molecular patterns initiates signaling cascades leading to morphological and phenotypic maturation. LÄS MER

  4. 23. The role of autoantibodies in inflammatory myopathies

    Författare :Sevim Barbasso Helmers; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Idiopathic inflammatory myopathies; polymyositis; dermatomyositis; inclusion body myositis; ILD; IVIG; IFN; BAFF; endothelial cells; anti-Jo-1;

    Sammanfattning : Polymyositis (PM), dermatomyositis (DM) and inclusion body myositis (IBM), collectively called myositis, are chronic inflammatory myopathies. These disease subsets are heterogeneous but share some features, such as skeletal muscle weakness and inflammatory cell infiltrates in muscle tissue. LÄS MER

  5. 24. Studies of cellular pathogenesis in experimental autoimmune encephalomyelitis

    Författare :Judit Wefer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :EAE; MS; autoimmunity; DNA vaccine; antigen-specific therapies;

    Sammanfattning : In this thesis, I have studied antigen-specific therapeutic interventions of experimental autoimmune encephalomyelitis (EAE) and aimed to understand the respective roles of different cell subsets in initiation and perpetuation of disease. EAE is a commonly used animal model for the human disease Multiple Sclerosis (MS), a demyelinating disease mainly affecting young adults. LÄS MER

  7. 25. Regulatory T cells in type 1 diabetes: the role of IL-35 in counteracting the disease

    Författare :Kailash Singh; Thomas Mandrup-Poulsen; Uppsala universitet; []
    Nyckelord :IL-35; regulatory T cells; type 1 diabetes; LADA; kidney and diabetic nephropathy; Medicinsk vetenskap; Medical Science; Immunologi; Immunology; Endocrinology and Diabetology; Endokrinologi och Diabetologi;

    Sammanfattning : Type 1 diabetes (T1D) is etiologically considered as an autoimmune disease, where insulin-producing β-cells are damaged by autoimmune attacks. Regulatory T (Treg) cells are immune homeostasis cells. In the present thesis I aimed to investigate the role of Treg cells and other immune cells in the early development of T1D. LÄS MER