Sökning: "DAP12"

Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet DAP12.

  1. 1. Regulation of NK cell activity : studies of DAP12-associated receptors in immune synapse formation and in responses to cytomegalovirus infection

    Författare :Hanna Sjölin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NK cells; DAP12; MCMV Cytokines; Receptors; Signaling; packages;

    Sammanfattning : Natural killer (NK) cell effector functions are important for innate resistance against tumor cells and viral infections. NK cells display a broad range of inhibitory and activating receptors on the cell surface, which ensure specificity. LÄS MER

  3. 2. TRAPC : a novel triggering receptor expressed on antigen presenting cells

    Författare :Rutger van der Holst; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :TREM; DAP12; Receptors; Signaling; Antigen presenting cells;

    Sammanfattning : The triggering receptor expressed on myeloid cells (TREM) family of receptors plays an important role in innate immunity. They have been described to regulate the course of sepsis, DC maturation, bone modulation and microglial function, and as markers for bacterial infections. LÄS MER

  4. 3. Diabetes pathogenesis : role of natural killer cells, T cells and a novel neuropeptide

    Författare :Hanna Brauner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Diabetes is a major health problem affecting nearly 5% of the population world wide. It is a heterogeneous group of diseases with the autoimmune type 1 diabetes (T1D) and the metabolic type 2 diabetes (T2D) being the major types. LÄS MER

  5. 4. Macrophage antigen expression in breast and colorectal cancers : A consequence of macrophage - tumour cell fusion?

    Författare :Ivan Shabo; Joar Svanvik; Bengt Gustavsson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Carcinogenesis is a sophisticated biological process consisting of a series of progressive changes in somatic cells from premalignant to malignant phenotype. Despite the vast information available about cancer cells, the origin of cancer and cause of metastasis still remain enigmatic. LÄS MER

  7. 5. NK cell recognition : adaptability to host factors in normal and diabetic mice

    Författare :Sofia Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Natural Killer; NK cell; education; Non obese diabetic; NOD; diabetes; activation; graft; rejection; in vivo; method; receptor; repertoire;

    Sammanfattning : The overall aim of this thesis was to understand the rules, which guide NK cell behavior in vivo. NK cells are part of the innate immune system and are important in defense against certain virus infections and tumorigenic cells. They also play a role in rejecting bone marrow grafts. LÄS MER