Sökning: "Idiopathic inflammatory myopathies"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden Idiopathic inflammatory myopathies.

  1. 1. Pathogenic mechanisms in idiopathic inflammatory myopathies

    Författare :Cecilia Grundtman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Idiopathic inflammatory myopathies (IIMs) are chronic inflammatory disorders characterized by muscle weakness, by low muscle endurance, and by inflammation in skeletal muscle tissue. The pathogenesis and etiology of these conditions are yet not fully understood and several different mechanisms are likely to be involved. LÄS MER

  2. 2. Molecular mechanisms in idiopathic inflammatory myopathies

    Författare :Mei Zong; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Myositis is a group of rare autoimmune diseases. Muscle weakness and fatigue are the dominant symptoms and inflammation with T cells and macrophages is a characteristic finding in muscle tissue. LÄS MER

  3. 3. Immunopathogenic mechanisms in inflammatory myopathies

    Författare :Pernilla Englund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Myositis; capillaries; muscle fibers; IL-1 alpha; MHC; adhesion molecules;

    Sammanfattning : The idiopathic inflammatory myopathies (IIMs) are characterized by symmetrical, proximal muscle weakness and by inflammatory infiltrates in muscle tissue. Based on different clinical as well as histopathological features the IlMs can be separated into polymyositis (PM), dermatomyositis (DM) and inclusion body myositis (IBM). LÄS MER

  4. 4. Studies on interleukin-1 in idiopathic inflammatory myopathies

    Författare :Christina Dorph; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The idiopathic inflammatory myopathies (IIM): polymyositis (PM), dermatomyositis (DM) and inclusion body myositis (IBM) are chronic rheumatic muscle diseases of unknown origin that are characterized by muscle weakness and by inflammatory infiltrates in the skeletal muscle. Treatment with glucocorticoids and other immunosuppressive agents has improved outcome but not all patients respond to this treatment and most patients have only a partial response and side effects are common. LÄS MER

  5. 5. Characterization of immune specificities in idiopathic inflammatory myopathies

    Författare :Angeles Shunashy Galindo-Feria; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Idiopathic inflammatory myopathies (IIM or myositis) are a group of rheumatic autoimmune diseases characterised by skeletal muscle inflammation and weakness, and are associated with high morbidity and mortality. The diagnosis integrates several subgroups of muscular disorders with autoimmune backgrounds, where identifying myositis-specific and associated autoantibodies play an essential role. LÄS MER