Sökning: "ILD"
Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet ILD.
1. The role of autoantibodies in inflammatory myopathies
Sammanfattning : Polymyositis (PM), dermatomyositis (DM) and inclusion body myositis (IBM), collectively called myositis, are chronic inflammatory myopathies. These disease subsets are heterogeneous but share some features, such as skeletal muscle weakness and inflammatory cell infiltrates in muscle tissue. LÄS MER
2. Interstitial lung disease in polymyositis and dermatomyositis
Sammanfattning : Polymyositis and dermatomyositis are rare disease entities affecting skeletal muscle and other organs such as the lungs. Interstitial lung disease (ILD) is increasingly recognized as a serious complication of poly-/dermatomyositis. LÄS MER
3. Systemic sclerosis : vascular, pulmonary and immunological aspects
Sammanfattning : In systemic sclerosis (SSc), interstitial lung disease (ILD) and engagement of the vascular system lead to increased morbidity and mortality. The aim of this thesis was to elucidate, in a consecutively included cohort of SSc (limited and diffuse) patients (n = 33), the T cell cytokine profile driving the disease in ILD and to explore the role of matrix metalloproteinase 9 (MMP-9) and its inhibitor: tissue inhibitor of metalloproteinase 1 (TIMP-1) in the extracellular matrix (ECM) degrading process leading to fibrous scarring and honey combing. LÄS MER
4. BRICHOS - a Novel Anti-Amyloid Chaperone : studies on pro-surfactant protein C
Sammanfattning : Lung surfactant protein C (SP-C) is a 35-residue, transmembrane (TM) peptide that is extremely hydrophobic and lacks known homologous proteins. Due to a high content in Val residues in the α-helical TM part, SP-C can spontaneously convert into β-sheet aggregates. LÄS MER
5. Immunological markers and clinical characteristics of pulmonary inflammation
Sammanfattning : Interstitial lung diseases (ILD) includes a broad spectrum of disorders affecting the lung parenchyma. Common to these conditions is the exacerbated pulmonary immunological response leading to inflammation, disordered tissue healing, and, in a proportion of patients, chronic pulmonary fibrosis. LÄS MER