Sökning: "Plasmacytoid dendritic cell"

Visar resultat 6 - 10 av 34 avhandlingar innehållade orden Plasmacytoid dendritic cell.

1. 6. Regulation of the germinal center response by T follicular helper cells and type I interferons

   Författare :Madelene Dahlgren; Adaptivt immunförsvar; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Germinal Center; T follicular helper cell; type I interferon; dendritic cell; adjuvant; differentiation; IgG;

   Sammanfattning : The protective effect of most currently available vaccines is dependent on high-affinity antibodies and long lived B cell memory, which develop within organized structures of secondary lymphoid organs called germinal centers (GCs). GC formation is supported by T follicular helper (Tfh) cells, a subset of CD4+ T cells that develop in parallel to other effector T cells and specifically localizes to B cell follicles. LÄS MER

3. 7. Endogenous Type I Interferon Inducers in Systemic Autoimmune Diseases

   Författare :Tanja Lövgren; Lars Rönnblom; Gunnar Alm; Maija-Leena Eloranta; Andrej Tarkowski; Uppsala universitet; []
   Nyckelord :Medicine; Systemic lupus erythematosus; Sjögren s syndrome; type I interferon; plasmacytoid dendritic cell; natural interferon-producing cell; immune complex; RNP; Ro SSA; La SSB; Medicin;

   Sammanfattning : Patients with systemic lupus erythematosus (SLE) have elevated levels of interferon (IFN)-α in blood and IFN-α-producing cells in tissues. In the present thesis, we investigate the mechanisms behind the upregulated IFN-α-production in SLE and also show that the IFN-α system is activated in primary Sjögren’s syndrome (pSS), with IFN-α-producing cells in the major affected organ, the salivary glands. LÄS MER

4. 8. Human cytomegalovirus and dendritic cell interaction : role in immunosupression and autoimmunity

   Författare :Stefania Varani; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cytomegalovirus; myeloid dendritic cells; plasmacytoid dendritic cells; immunosuppression; autoimmunity.;

   Sammanfattning : Human cytomegalovirus (HCMV) infection is a major cause of morbidity and mortality in patients with an impaired immune system. The virus itself can cause transitory but significant immunosuppression in immunocompetent as well as immunocompromised infected individuals. LÄS MER

5. 9. Circulating Human Basophils and Dendritic Cell Subsets. Aspects of antigen recognition and presentation in type I allergic immune responses

   Författare :Frida Rydnert; Institutionen för immunteknologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dendritic cells; basophils; allergy; pattern-recognition receptors; allergen-specific immunotherapy;

   Sammanfattning : Allergic diseases currently affect a third of the population in the industrialized parts of the world. Despite this, the cellular and molecular mechanisms involved in the induction and activation of allergic diseases are not fully clarified. LÄS MER

7. 10. Regulation of Type I Interferon Production in Plasmacytoid Dendritic Cells : Effect of Genetic Factors and Interactions with NK Cells and B Cells

   Författare :Olof Berggren; Maija-Leena Eloranta; Niels Heegaard; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic lupus erythemtosus; IFN-alpha; autoimmunity; immune complex; single nuclear polymorphisms; Medicinsk vetenskap; Medical Science;

   Sammanfattning : The type I interferon (IFN) system plays a central role in the etiopathogenesis of many autoimmune diseases, e.g. systemic lupus erythematosus (SLE). Activation of the type I IFN system in SLE is promoted by endogenous nucleic acid-containing immune complexes (ICs) which stimulate plasmacytoid dendritic cells (pDCs). LÄS MER