Sökning: "PTEN"

Visar resultat 6 - 10 av 65 avhandlingar innehållade ordet PTEN.

  1. 6. Protein kinases and phosphatases in B-cell lymphoma

    Författare :Marie Fridberg; Tumörmikromiljö; []
    Nyckelord :HePTP; PTEN; PKC-beta 2; B-cell; lymphoma; kinases; ZAP70; phosphatase; SHP2;

    Sammanfattning : Around 2000 persons are diagnosed with lymphoma in Sweden each year. There are many subgroups described for this form of cancer and the great majority is derived from B-cells. The most common subgroup is Diffuse large B-cell lymphoma (DLBCL), a highly aggressive disease where only half of the patients are cured. LÄS MER

  3. 7. PTEN and Akt signalling in Alzheimer’s disease

    Författare :Annika Rickle; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :PTEN; Akt; GSK3beta; post-mortem brain; rat primary cortical neurons;

    Sammanfattning : Akt / protein kinase B is an important cell survival kinase that modulates the activity of a range of pro-apoptotic proteins. A major downstream target of Akt is glycogen synthase kinase-3beta (GSK3beta) that phosphorylates the microtubule-associated protein tau. LÄS MER

  4. 8. Pharmacological targeting of nonsense mutant TP53 and PTEN in cancer

    Författare :Angelos Heldin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The TP53 tumor suppressor gene encodes p53 and is inactivated by mutations in around half of all human tumors. Approximately 11% of TP53 mutations are nonsense mutations, resulting in the premature termination of translation and the production of truncated and non-functional p53 proteins. LÄS MER

  5. 9. Translational readthrough of nonsense mutant TP53, RB1 and PTEN tumor suppressor genes as a strategy for novel cancer therapy

    Författare :Mireia Palomar Siles; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A nonsense mutation causes a premature termination codon in the coding sequence of an mRNA. This leads to termination of translation and release of a truncated and in most cases non-functional protein. LÄS MER

  7. 10. Molecular genetic aspects of renal cell carcinoma development

    Författare :Andrei Alimov; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Kidney tumor; RCC; LOH; CGH; SKY; PTEN; chromosome 3p; chromosome 10q; chromosome 14q;

    Sammanfattning : Renal cell carcinoma (RCC) is the most common tumor of the renal parenchyma. The aim of this study was to further characterize known as well as new genetic abnormalities in a clinical material of RCC, as well as in established cell lines to gain more information about etiological and progression factors. LÄS MER