Sökning: "PTEN"

Visar resultat 21 - 25 av 65 avhandlingar innehållade ordet PTEN.

  1. 21. Studies of phosphatidylinositol 3 kinase (PI3K) signaling pathway in mammalian ovarian follicle activation and development

    Författare :Singareddy Rajareddy; Kui Liu; Anneli Stavreus-Evers; Umeå universitet; []
    Nyckelord :oocyte; follicular development; P13K pathway; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : The intra-oocyte signaling pathways that control oocyte growth and early follicular development are largely unknown. The aim of this thesis was to investigate the regulation and functions of phosphatidylinositol 3 kinase (PI3K) pathway in the oocyte, focusing in the roles of Foxo3a, p27, and Pten (phosphatase and tensin homolog deleted on chromosome ten). LÄS MER

  3. 22. The functional roles of the intra-oocyte phosphatidylinositol 3-kinase (PI3K) signaling in controlling follicular development in mice

    Författare :Krishna Rao Jagarlamudi; Kui Liu; Lena Sahlin; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oocyte; PI3K signaling; primordial follicle; Obstetrics and gynaecology; Obstetrik och gynekologi; Developmental Biology; miljömedicinsk utvecklingsbiologi;

    Sammanfattning : The key functions of the mammalian ovary are the production of fertilizable oocytes and thesecretion of steroid hormones. At the time of birth the human ovary is composed of basic unitstermed primordial follicles. Primordial follicles are long-lived structures in the ovary and some ofthem last until the woman reaches menopause. LÄS MER

  4. 23. Responses to Tumour initiating factors and Regulation of Normal and Malignant Haematopoiesis

    Författare :Eva Diffner; Malmö Patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The haematopoietic stem cell (HSC) resides within a specific environment enabling it to retain its self-renewal capacity or quiescent state. It is proposed that the HSC niche is hypoxic, a milieu within which the HSC is protected from intrinsic and extrinsic stimuli. LÄS MER

  5. 24. Molecular determinants of glioma subsets with distinct histology or sensitivity to signal transduction inhibitors

    Författare :Daniel Hägerstrand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Gliomas are brain tumors that currently are treated with surgery, radiation and chemotherapy. Less than 7.5% of patients with GBM survive more than 2 years after diagnosis. LÄS MER

  7. 25. Genetic variation of tight junction structures in intestinal inflammation

    Författare :Elisabeth Norén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The epithelial barrier facing the external environment in the gastrointestinal (GI) tract is comprised of several components, including the tight junction (TJ) structures observed for the first time in 1963. TJ structures, which are multiprotein complexes composed of transmembrane proteins and a diverse spectrum of intracellular components, create a primary barrier to diffusion of ions, solutes, and water and they concomitantly prevent permeation of pro-inflammatory factors, such as pathogens, toxins, and antigens. LÄS MER