Sökning: "SHP2"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet SHP2.

  1. 1. Protein kinases and phosphatases in B-cell lymphoma

    Författare :Marie Fridberg; Tumörmikromiljö; []
    Nyckelord :HePTP; PTEN; PKC-beta 2; B-cell; lymphoma; kinases; ZAP70; phosphatase; SHP2;

    Sammanfattning : Around 2000 persons are diagnosed with lymphoma in Sweden each year. There are many subgroups described for this form of cancer and the great majority is derived from B-cells. The most common subgroup is Diffuse large B-cell lymphoma (DLBCL), a highly aggressive disease where only half of the patients are cured. LÄS MER

  3. 2. Control of neuronal survival, migration and outgrowth by GDNF and its receptors

    Författare :Maurice Perrinjaquet; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Glial cell line-derived neurotrophic factor (GDNF) is the prototypical member of a family of growth factors that are indispensable in nervous system development and maintenance. GDNF signals by binding to a multi-component receptor complex comprised of the ligand-binding subunit GFRα1 and the signaling subunit RET or NCAM. LÄS MER

  4. 3. Protein tyrosine phosphatases : taking a 'redoxionist' look at PDGFR signaling

    Författare :Jeroen Frijhoff; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Protein Tyrosine Phosphatases (PTPs) are oxidized and inactivated by reactive oxygen species (ROS) upon stimulation of a wide range of cell surface receptors, including the platelet-derived growth factor (PDGF) receptor (PDGF R). Signaling via this receptor tyrosine kinase stimulates cell proliferation and migration, and it is associated with cancer and cardiovascular diseases. LÄS MER

  5. 4. Redox-regulation of PTPs : mechanisms and impact on PDGFR signaling

    Författare :Markus Dagnell; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Protein tyrosine phosphatases (PTPs) are reversibly oxidized upon activation of platelet-derived growth factor receptor beta (PDGFβR). Dys-regulation of the PDGFβR signaling pathway is associated with several diseases, including cancers and cardiovascular disease, and is thus a known driver of disease progression. LÄS MER

  7. 5. Role of FLT3 in Acute Myeloid Leukemia: Molecular mechanisms and Therapeutic opportunities

    Författare :Sausan Moharram; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LEUKEMIA; AML; Mutations; FLT3; Signlaing;

    Sammanfattning : Acute myeloid leukemia (AML) is a highly heterogeneous blood disease which is characterized by different mutations and chromosomal rearrangements. Nearly 60% of genetic alterations have been found in AML patients involve in signaling pathways including signaling of tyrosine kinase receptor FLT3. LÄS MER