Sökning: "Angelos Heldin"

Hittade 1 avhandling innehållade orden Angelos Heldin.

1. 1. Pharmacological targeting of nonsense mutant TP53 and PTEN in cancer

   Författare :Angelos Heldin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The TP53 tumor suppressor gene encodes p53 and is inactivated by mutations in around half of all human tumors. Approximately 11% of TP53 mutations are nonsense mutations, resulting in the premature termination of translation and the production of truncated and non-functional p53 proteins. LÄS MER