Sökning: "PIB"

Visar resultat 16 - 20 av 21 avhandlingar innehållade ordet PIB.

1. 16. Polymorphic protein aggregation in tauopathies

   Författare :Alexander Sandberg; Per Hammarström; Sofie Nyström; Wei-Feng Xue; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Alzheimer’s disease(s) comprises one of the most common and costly neurodegenerative diseases. With a larger population and an increasing life expectancy, amyloid diseases (with age as one of the most prominent risk factors) will generate an even larger burden on healthcare. LÄS MER

3. 17. PET and the Multitracer Concept: An Approach to Neuroimaging Pathology

   Författare :Henry Engler; Bengt Långström; Göran Hedenstierna; Juha Rinne; Uppsala universitet; []
   Nyckelord :Neurosciences; PET Positron Emission Tomography ; multitracer; neuroimaging pathology; astrocytes; microglia; neurodegeneration; amyloid; AD; CJD; PD; Neurovetenskap;

   Sammanfattning : Patients suffering from different forms of neurodegenerative diseases, such as: Creutzfeldt Jacob Disease (CJD), Alzheimer disease (AD), mild cognitive impairment (MCI), frontotemporal dementia and Parkinson’s disease (PD) were examined with Positron Emission Tomography (PET) and the combination of different radiotracers: 15O-water, N-[11C-methyl]-L-deuterodeprenyl (DED), [18F] 2-fluorodeoxyglucose: (FDG), N-methyl-[11C]2-(4-methylaminophenyl)-6-hydroxybenzothiazole (PIB) and L-[11C]-3,4-dihydroxiphenyl-alanine (DOPA). The radiotracers and the combinations of different radiotracers were selected with the intention to detect, in the brain, patterns of neuronal dysfunction, astrocytosis, axon degeneration or protein aggregation (amyloid), in the brain which are pathognomonic for specific diseases and may contribute to improve clinical differential diagnoses. LÄS MER

4. 18. The heart in hereditary transthyretin amyloidosis : clinical studies on the impact of amyloid fibril composition

   Författare :Björn Pilebro; Ole Suhr; Henning Mölgaard; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Amyloidosis; Transthyretin; Cardiomyopathy; Echocardiography; Scintigraphy; Positron emission tomography; cardiovascular disease; hjärt- och kärlforskning; kardiologi; Cardiology; Clinical Physiology; klinisk fysiologi;

   Sammanfattning : Background Hereditary transthyretin amyloid (ATTRm) amyloidosis is a systemic disease mainly affecting the peripheral nervous system and the heart. The disease is inherited in an autosomal dominant manner with a varying penetrance. It is caused by mutations in the transthyretin (TTR) gene. Today more than 100 disease causing mutations are known. LÄS MER

5. 19. Characterization of the novel “Uppsala mutation” causing a familial form of early onset Alzheimer’s disease

   Författare :María Pagnon de la Vega; Martin Ingelsson; Dag Sehlin; Vilmantas Giedraitis; Gunnar Gouras; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; neurodegeneration; amyloid precursor protein; APP processing; amyloid beta; transgenic mouse model;

   Sammanfattning : The Alzheimer’s disease (AD) brain displays extracellular plaques of amyloid-β (Aβ), neurofibrillary tangles of tau and neuronal loss. The 40-42 amino acid Aβ peptide is formed from the amyloid precursor protein (APP) by β-secretase and γ-secretase, while α-secretase prevents Aβ generation. LÄS MER

7. 20. Sharing the doughnut : Exploring sustainable and just futures

   Författare :Eléonore Fauré; Ulrika Gunnarsson-Östling; Göran Finnveden; Frances Fahy; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Sustainability goals; goal conflicts; trade-offs; environmental justice; futures studies; backcasting; future scenarios; climate and energy targets; sustainability assessments; Objectifs de durabilité; Conflit d objectifs de durabilité; justice environnementale; prospective; backcasting; évaluation d impacts de durabilité; Hållbarhetsmål; målkonflikter; miljörättvisa; framtidsstudier; backcasting; framtidsscenarier; klimat och energimål; hållbarhetsutvärderingar; Planering och beslutsanalys; Planning and Decision Analysis;

   Sammanfattning : Despite decades of international discussions or summits on the need to radically reduce e.g. increasing concentrations of greenhouse gases (GHGs) or biodiversity loss, these are still rising. LÄS MER