Sökning: "PDGF"

Visar resultat 21 - 25 av 184 avhandlingar innehållade ordet PDGF.

  1. 21. Neural Stem Cell Differentiation and Migration

    Författare :Anna Erlandsson; Karin Forsberg-Nilsson; Bengt Westermark; Christer Betsholtz; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; CNS; stem cells; neuron; PDGF; SCF; differentiation; migration; ERK; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; Medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Neural stem cells are the precursors of neurons, astrocytes and oligodendrocytes. During neural development, the division of stem cells takes place close to the lumen of the neural tube, after which they migrate to their final positions within the central nervous system (CNS). LÄS MER

  3. 22. Neural Stem and Progenitor Cells : Cellular Responses to Known and Novel Factors

    Författare :Jimmy Larsson; Karin Forsberg-Nilsson; Ola Hermanson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neural stem cell; differentiation; proliferation; migration; PDGF; SCF; NRBP2; medulloblastoma; Biochemistry; Biokemi; Medical Biochemistry; Medicinsk biokemi;

    Sammanfattning : Neural stem cell self-renewal and differentiation are tightly regulated events during CNS development, leading to cell division into new neural stem cells or the formation of neurons and glial cells. This thesis focuses on the cellular responses induced by known and novel factors in neural stem and progenitor cells (NSPCs). LÄS MER

  4. 23. A Short Thesis about Growth Factors in Gliomas

    Författare :Göran Hesselager; Eric Holland; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; glioma; mouse model; PDGF; EGFR; activation; Patologi; Pathology; Patologi; Pathology; patologi;

    Sammanfattning : Glioblastoma multiforme (GBM) is the most common form of primary brain tumor in humans. Its aggressive and infiltrative growth into the brain, and, at best, only partial sensitivity to radiotherapy and chemotherapy, renders it extremely difficult to treat and survival remains dismal. LÄS MER

  5. 24. The Roles of Growth Factor Interactions and Mechanical Tension in Angiogenesis

    Författare :Ludvig Petersson; Pär Gerwins; Filip Farnebo; Uppsala universitet; []
    Nyckelord :angiogenesis; myofibroblast; wound healing; VEGF; FGF; PDGF; endocan; endothelial cell; vascularization; MEDICINE; MEDICIN; Medicin; Medicine;

    Sammanfattning : Angiogenesis, the formation of new blood vessels from preexisting ones through creation of new vessel branch points by sprouting or vessel splitting, is an important part of tissue growth in both physiological processes like wound healing and pathological conditions such as cancer. Growth factors like VEGF-A, FGF-2 and PDGF-BB are involved in both types of angiogenesis. LÄS MER

  7. 25. Interplay Between Cell of Origin and Oncogenic Activation in Glioma

    Författare :Yiwen Jiang; Lene Uhrbom; Anders Persson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioma; PDGF; cell of origin; Sox5; glioma initiating cells; Oncology; Onkologi;

    Sammanfattning : Glioma is the most frequent primary tumor of the central nervous system. By using the RCAS/tv-a mouse glioma model, we have studied mechanisms controlling glioma development and the effect of cell of origin on these processes.SOX5 was identified as a brain tumor locus in a retroviral insertional mutagenesis screen of PDGF-B induced mouse gliomas. LÄS MER