Sökning: "PDGF"
Visar resultat 16 - 20 av 184 avhandlingar innehållade ordet PDGF.
16. Cardiovascular role of PDGF-B in development and disease. Studies in genetically engineered mice
Sammanfattning : Platelet-derived growth factor B (PDGF-B) is vital for microvascular development, and retention of PDGF-B to extracellular matrix (ECM) is important in this process. However, the role and source of PDGF-B in development of macrovascular function is disputed. LÄS MER
17. Modulation of PDGF receptors function by posttranslational modifications
Sammanfattning : The platelet-derived growth factor receptors (PDGFRs) play important roles in multiple cellular processes including cell survival, cell growth and cell migration. Dysregulation of PDGFRs causes aberrant PDGF signaling, which leads to various diseases. LÄS MER
18. Regulation of the platelet-derived growth factor β-receptor
Sammanfattning : Growth factors are important signalling molecules, regulating cell growth, as well as cell movement, differentiation and apoptosis. They bind to specific receptors on the cell surface causing activation of the receptors. Activated receptors then attract adaptor molecules that brings the signal further into the cell. LÄS MER
19. Role of extracellular retention of platelet-derived growth factor-B. Functions in development and disease
Sammanfattning : During development, the cell secretes growth and differentiation factors (GDFs) to the surrounding microenvironment. These factors are often key regulators of organogenesis and embryogenesis. Several GDFs carry sequences that mediate specific interaction with molecules of the extracellular matrix (ECM) that surrounds the cell. LÄS MER
20. Tumor angiogenesis. Regulation of mural cell recruitment and endothelial sprouting
Sammanfattning : The formation of new blood vessels is an inherent part of many physiological and pathological processes. Currently, there is a strong hope pathological situations like stroke, diabetic retinopathy and cancer may be affected by pharmacological regulators of blood vessel formation. LÄS MER