Sökning: "Neurotropic"

Visar resultat 6 - 10 av 22 avhandlingar innehållade ordet Neurotropic.

  1. 6. Host-pathogen interactions during tick-borne flavivirus infection : pathogenesis, tropism and tools

    Författare :Ebba Rosendal; Anna K. Överby Wernstedt; Emma Nilsson; Jonathan D. Gilthorpe; Sonja M. Best; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tick-borne encephalitis virus; Langat virus; pathogenesis; type I interferons; central nervous system; neuroinflammation; structural proteins; Infectious Diseases; infektionssjukdomar; mikrobiologi; Microbiology;

    Sammanfattning : Tick-borne encephalitis virus (TBEV) is a neurotropic member of the genus Flavivirus. It may transmit to humans through the bite of an infected tick or consumption of unpasteurized dairyproducts, and causes tick-borne encephalitis (TBE). TBE constitutes a significant health burden in Eurasia, with more than 10,000 cases reported every year. LÄS MER

  3. 7. Neurological complications after stem cell transplantation in children

    Författare :Johanna Rubin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Allogeneic haematopoietic stem cell transplantation (HSCT) is a well established method used in the treatment of a number of benign and malignant blood diseases, inborn errors of metabolism and severe congenital immunodeficiency syndromes. Around 60 children are transplanted in Sweden every year. LÄS MER

  4. 8. Improving the diagnostic armamentarium of lung cancer

    Författare :Hedvig Elfving; Patrick Micke; Fredrik Pontén; Marika Nestor; Reinhard Büttner; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lung cancer; tissue microarray; immunohistochemistry; targeted therapy; immunotherapy; checkpoint inhibitors; immune microenvironment; prognosis; biomarkers; immune cells.;

    Sammanfattning : Lung cancer is the leading cause of cancer-related death globally, with non-small cell lung cancer (NSCLC) constituting 85% of cases. The introduction of immunotherapies and targeted therapies have dramatically improved the prognosis and outcome for a subset of patients, and stressed the development of diagnostic tools for effective patient selection. LÄS MER

  5. 9. Imbalanced kynurenine pathway in schizophrenia and depression : immunological and genetic aspects

    Författare :Xicong Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Kynurenic acid (KYNA), an end metabolite of the kynurenine pathway along tryptophan degradation, has gained increasing interest in the pathophysiology of psychiatric disorders. Elevated levels of KYNA have been found in the cerebrospinal fluid (CSF) and in the postmortem brain of patients with schizophrenia and bipolar disorder with psychotic symptoms. LÄS MER

  7. 10. New perspectives on pathology in Huntington's disease - characterization of hypothalamic changes

    Författare :Sanaz Gabery; Translationell neuroendokrinologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington’s disease; huntingtin; hypothalamus; oxytocin; vasopressin; orexin; CART; neuroendocrinology; MRI; 3 Tesla; volymetric analysis;

    Sammanfattning : Huntington’s disease (HD) is a neurodegenerative disorder caused by an expansion of the CAG repeat in the huntingtin gene. Non-motor symptoms and signs such as psychiatric disturbances and metabolic dysfunction are also part of the disease manifestation. These symptoms often precede the motor symptoms by decades. LÄS MER