Sökning: "neuroendocrinology"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet neuroendocrinology.

  1. 1. New perspectives on pathology in Huntington's disease - characterization of hypothalamic changes

    Författare :Sanaz Gabery; Translationell neuroendokrinologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington’s disease; huntingtin; hypothalamus; oxytocin; vasopressin; orexin; CART; neuroendocrinology; MRI; 3 Tesla; volymetric analysis;

    Sammanfattning : Huntington’s disease (HD) is a neurodegenerative disorder caused by an expansion of the CAG repeat in the huntingtin gene. Non-motor symptoms and signs such as psychiatric disturbances and metabolic dysfunction are also part of the disease manifestation. These symptoms often precede the motor symptoms by decades. LÄS MER

  3. 2. Psychiatric and metabolic disturbances in experimental models of Huntington’s disease

    Författare :Sofia Hult Lundh; Translationell neuroendokrinologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington’s disease; huntingtin; hypothalamus; depression; anxiety; metabolism; neuroendocrinology; mouse models; BACHD; rAAV vectors; leptin;

    Sammanfattning : Non-motor symptoms and signs such as metabolic and psychiatric disturbances have been reported to occur early in Huntington’s disease (HD), a fatal neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. However, there is a lack of understanding of the underlying neurobiological mechanisms responsible for the early non-motor features. LÄS MER

  4. 3. Hypothalamic and Metabolic Dysfunction in Genetic Models of Huntington’s Disease

    Författare :Rana Soylu Kucharz; Translationell neuroendokrinologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Huntington’s Disease; Huntingtin; Hypothalamus; Metabolism; Obesity; orexin; PVN; BAT; TH; neuroendocrinology;

    Sammanfattning : Huntington’s disease (HD) is caused by a CAG trinucleotide repeat expansion in the huntingtin (HTT) gene. HD is an inherited progressive neurodegenerative disorder manifested by the wide array of motor dysfunctions, as well as non-motor symptoms. LÄS MER

  5. 4. Neuroendocrinology of agonostic interaction and social signalling in Artic charr (Salvelinus alpinus) : Studies on the neuroendocrine regulation of aggressive behaviour, stress responses and skin colour

    Författare :Erik Höglund; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Brain monoamines; social signalling; POMC; skin colour; stress; Salmonid; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi; limnologi; Limnology;

    Sammanfattning : This thesis shows that socially subordinate Arctic charr (Salvelinus alpinus) display elevated brain serotonergic (5-HT) and norepinephric activity along with a chronic activation of the hypothalamic-pituitary-interrenal (HPI) axis, including elevated plasma concentrations of á-MSH. Furthermore, subordinate fish showed an inhibition of aggressive behaviour and darker body coloration, skin darkness being positively correlated with plasma á-MSH. LÄS MER

  7. 5. Acupuncture in reproductive medicine. Applications in human assisted reproduction and aspects of clinical and experimental neuroendocrinology

    Författare :Elisabet Stener-Victorin; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; electro-acupuncture; blood flow impedance; circulation; uterine artery; in-vitro fertilization; oocyte aspiration; polycystic ovary syndrome; experimentally induced PCO; anovulation; gonadotropins; steroids; neuropeptides; b-endorphin; nerve growth factor; corticotropin-releasing factor.;

    Sammanfattning : The use of acupuncture in the area of reproductive medicine is relatively new, and it has been rather poorly investigated in the past. When muscle afferents are stimulated by acupuncture in somatic segments related to the innervation of the ovaries and the uterus, functional changes occur in the neural substrate that may influence reproductive function and result in peripheral, segmental and central effects. LÄS MER