Sökning: "N-myc."

Visar resultat 6 - 10 av 16 avhandlingar innehållade ordet N-myc..

  1. 6. Regulation and function of the Mad/Max/Myc network during neuronal and hematopoietic differentiation

    Författare :Anne Hultquist; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Myc; Mad1; neuroblastoma; hematopoiesis; phorbol ester; retinoic acid; interferon-g; TGF-b; differentiation.; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : The Mad/Max/Myc transcription factor network takes part in the control of vital cellular functions such as growth, proliferation, differentiation and apoptosis. Dimerization with the protein Max is necessary for the Myc-family of oncoproteins and their antagonists, the Mad-family proteins, to regulate target genes and carry out their intended functions. LÄS MER

  3. 7. The Wilms' tumor gene 1 (WT1) and leukemia -new insights and further complexity

    Författare :Emelie Svensson; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; onkologi; cancer; Haematology; extracellular fluids; Hematologi; extracellulära vätskor; Cytologi; cancerology; oncology; Cytology; Medicin människa och djur ; Medicine human and vertebrates ; Cofilin 1; NDRG2; IRF-8; BCR ABL1; hematopoiesis; Wilms´ tumor gene 1; leukemia;

    Sammanfattning : The Wilms tumor gene 1 (WT1) encodes a zinc-finger containing transcription factor which is highly expressed in immature hematopoietic progenitor cells. A high expression of WT1 and the presence of somatic mutations in acute leukemia indicate a role for WT1 in the pathogenesis of leukemia. LÄS MER

  4. 8. Murine plasmacytomagenesis : an experimental model of B-cell neoplasia

    Författare :Santiago C Silva; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :mouse plasmacytomas; chromosomal translocation; chimeric mice; MYC-transgenic mice; ;

    Sammanfattning : A chromosomal translocation which results in the illegitimate activation of the c-myc proto-oncogene by one of the three immunoglobulin (Ig) loci is invariably associated with human Burkitt's Lymphoma (BL), mouse plasmacytoma (MPC) and rat immunocytomas (RIC). In the MPC system a genetic predisposition linked to the BALB/c strain has been suggested. LÄS MER

  5. 9. Fine needle aspiration cytology in diagnosis and management of childhood small round cell tumours

    Författare :Björn Fröstad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :child; adolescence; cytology; fine-needle aspiration; lymphoma; rhabdomyosarcoma; neuroblastoma; ganglioneuroma; Ewing s sarcoma; primitive neuroectodermal tumour; fluorescent in situ hybridisation FISH ; diagnosis; prognosis;

    Sammanfattning : Fine needle aspiration (FNA) cytology is accepted for diagnosing malignant tumours in adults. However, it has been slow in gaining acceptance among paediatricians and has only been used at some centres in the routine diagnosis of childhood tumours. LÄS MER

  7. 10. WILMS’ TUMOUR GENE 1 PROTEIN (WT1) – AN EFFECTOR IN LEUKEMOGENESIS?

    Författare :Karina Vidovic; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; WT1 delZ ; leukemia; BCR ABL1; hematopoiesis; NDRG2; IRF8; WT1;

    Sammanfattning : Wilms’ tumour gene 1 (WT1) encodes a zinc-finger transcription factor functioning as a key regulator in organ development. WT1 was first identified as a tumour suppressor gene due to its inactivation in Wilms’ tumour cases, a childhood kidney cancer. LÄS MER