Sökning: "chimeric mice"
Visar resultat 1 - 5 av 42 avhandlingar innehållade orden chimeric mice.
Sammanfattning : Inflammation plays an important role in atherosclerosis. One of the most potent pro-inflammatory cytokines is tumor necrosis factor-alpha (TNF-a), a cytokine identified to have a pathogenic role in chronic inflammatory diseases such as rheumatoid arthritis (RA). LÄS MER
Sammanfattning : Several methods have been developed to transfer components of the human immune system into mice. In particular, the adoptive transfer of human Iymphoid cells or tissues into mice with severe combined immunodeficiency (SCID mice) has demonstrated the general applicability of such an approach. LÄS MER
Sammanfattning : Thanks to the development of vaccines, children are these days protected against infectious diseases like polio, diphtheria and tetanus simply by receiving a few injections. Imagine a scenario where these injections would also result in protection against cancer. LÄS MER
Sammanfattning : MURINE PLASMACYTOMAGENESIS: AN EXPERIMENTAL MODEL OF B-CELL NEOPLASIA Santiago Silva C Microbiology and Tumorbiology Center (MTC) Karolinska Institute, S-171 77 Stockholm A chromosomal translocation which results in the illegitimate activation of the c-myc proto-oncogene by one of the three immunoglobulin (Ig) loci is invariably associated with human Burkitt's Iymphoma (BL), mouse plasmacytoma (MPC) and rat immunocytomas (RIC). In the MPC system a genetic predisposition linked to the BALB/c strain has been suggested. LÄS MER
Sammanfattning : In this PhD thesis the potential of T-cells as therapy for disease are explored. The applications of genetically modified T-cells for treatment of cancer and autoimmune disease; the functionality and optimal activation of T-cells are discussed. LÄS MER