Sökning: "Mad1"

Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet Mad1.

1. 1. Regulation and function of the Mad/Max/Myc network during neuronal and hematopoietic differentiation

   Författare :Anne Hultquist; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Myc; Mad1; neuroblastoma; hematopoiesis; phorbol ester; retinoic acid; interferon-g; TGF-b; differentiation.; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

   Sammanfattning : The Mad/Max/Myc transcription factor network takes part in the control of vital cellular functions such as growth, proliferation, differentiation and apoptosis. Dimerization with the protein Max is necessary for the Myc-family of oncoproteins and their antagonists, the Mad-family proteins, to regulate target genes and carry out their intended functions. LÄS MER

3. 2. The Myc network of growth regulators and its interplay with growth and differentiation signals

   Författare :Siqin Wu; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Myc; Mad1; p21Cip1; phorbol ester; IFN-g; TGF-b; differentiation; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

   Sammanfattning : The proto-oncogenes/tumor suppressor genes of the Myc/N4ax/Mad network encode transcription factors that are important regulators of cell growth, differentiation, and apoptosis and that are frequently implicated in tumor development. Regulation of their biological functions by growth/differentiation signals as well as their interplay with growth/differentiation signalling pathways play important roles in cell fate determination. LÄS MER

4. 3. Roles of Myc and Mad in cell cycle and apoptosis

   Författare :Ami Albihn; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Myc; Mad; cell cycle; apoptosis; differentiation; tumorigenesis; chemotherapy;

   Sammanfattning : The Myc network proteins are key mediators in regulation of cell growth, differentiation and apoptosis. They are basic region hehx-loop-helix/leucine zipper (bHLH/Zip) transcription factors that require hetero-dimerization with Max for specific DNA binding Mad family members are expressed primarily in differentiated tissues where they recruit histone deacetylase complexes via the mSin3 interaction domain (SID) to repress transcription of target genes and prevent cell growth In contrast, members of the Myc family activate target gene transcription by recruitment of histone acetyltransferases to their transcriptional activation domain (TAD), inducing proliferation and S phase entry. LÄS MER

5. 4. Modulating the activity of the c-Myc oncoprotein : implications for therapeutic treatment

   Författare :Per Hydbring; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : The Myc oncoprotein regulates numerous cellular processes and is frequently deregulated in cancer due to genetic lesions. However, in addition to its tumor promoting activity, Myc and other oncoproteins induce intrinsic safe-guard mechanisms against tumorigenesis like apoptosis and cellular senescence, which have to be overcome by additional genetic lesions for cellular transformation. LÄS MER

7. 5. Expression and activity of Myc network proteins during cell cycle progression and differentiation

   Författare :Nikita Popov; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Transcription factors of Myc network are the key regulators of cell proliferation, cell death and differentiation. Identified as a transforming oncogene, myc is the driving force of a variety of human cancers, and inactivation of myc in tumors can cause their rapid regression. LÄS MER