Sökning: "rhabdomyosarcoma"

Visar resultat 1 - 5 av 13 avhandlingar innehållade ordet rhabdomyosarcoma.

  1. 1. Somatic Genetic Variation in Children: from Mosaicism to Cancer

    Författare :Anders Valind; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Somatic Mosaicism; Cancer; Tumor heterogeneity; Neuroblastoma; Wilms Tumor; Rhabdomyosarcoma; Aneuploidy;

    Sammanfattning : This thesis concerns various aspects of somatic mosaicism and genetic intratumor heterogeneity in childhood cancer.In paper I, I show that aneuploidy in itself does not lead to the level of chromosomal instability that is typically seen in malignant cells. This finding strongly argues against the so called autocatalytic theory of carcinogenesis. LÄS MER

  3. 2. Genetic factors in childhood cancer. Associations between tumors in childhood and adulthood, and prevalence of germline TP53 mutations

    Författare :Susanne Magnusson; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Childhood cancer; hereditary factors; breast cancer; survival; hereditary breast and ovarian cancer; hereditary non-polyposis colorectal cancer; familial malignant melanoma; BRCA1; BRCA2; mismatch repair; CDKN2A; familial risk; multiple childhood tumors; Li-Fraumeni syndrome; TP53; adrenocortical carcinoma; choroid plexus tumors; rhabdomyosarcoma;

    Sammanfattning : The etiology of childhood cancer is largely unknown. Approximately 1-10% of all childhood tumors are associated with known cancer predisposition syndromes. However, the contribution may be underestimated due to the failure to detect patients with genetic susceptibility for cancer when relying on known family pattern and anomalies. LÄS MER

  4. 3. Hedgehog signaling in rhabdomyosarcoma : role of GLI factors and splice variants in signal transduction

    Författare :Ulrica Tostar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Rhabdomyosarcoma (RMS) is the most common soft-tissue childhood cancer. Deregulation of the Hedgehog (HH) signaling pathway, which is essential for proper embryonic development, has been implicated as a driving force for this cancer. LÄS MER

  5. 4. Nestin : filament formation and expression in myogenesis and muscle disorders

    Författare :Gunnar Sjöberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Intermediate filament; nestin; desmin; vimentin; myogenesis neuromusculardisorders; rhabdomyosarcoma;

    Sammanfattning : Intermediate filaments (IF), together with microfilaments and microtubules, are the major components of the cytoskeleton of eukaryotic cells. In myogenic cells three IF proteins are expressed; desmin, vimentin and nestin. LÄS MER

  7. 5. Fine needle aspiration cytology in diagnosis and management of childhood small round cell tumours

    Författare :Björn Fröstad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :child; adolescence; cytology; fine-needle aspiration; lymphoma; rhabdomyosarcoma; neuroblastoma; ganglioneuroma; Ewing s sarcoma; primitive neuroectodermal tumour; fluorescent in situ hybridisation FISH ; diagnosis; prognosis;

    Sammanfattning : Fine needle aspiration (FNA) cytology is accepted for diagnosing malignant tumours in adults. However, it has been slow in gaining acceptance among paediatricians and has only been used at some centres in the routine diagnosis of childhood tumours. LÄS MER