Sökning: "Metalloprotease"

Visar resultat 6 - 10 av 23 avhandlingar innehållade ordet Metalloprotease.

  1. 6. Characterization of FtsH proteases in the annual plant Arabidopsis thaliana

    Författare :Harald Aigner; Christiane Funk; Sacha Baginsky; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; biokemi; Biochemistry;

    Sammanfattning : Background FtsH is an ATP-dependent membrane-bound metalloprotease. A. thaliana contains 12 FtsH proteases localized in membranes of chloroplasts and mitochondria where they form homo- or hetero-hexameric complexes. FtsH11 – the main subject of this thesis – is located in the chloroplast envelope. LÄS MER

  3. 7. Phosphorylation regulates APP and Fe65, two key players in Alzheimer’s disease

    Författare :Preeti Menon; Anna-Lena Ström; Lennart Brodin; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alzheimer s disease; APP; Fe65; phosphorylation; RIP; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Alzheimer’s disease (AD) is a slow progressive neurodegenerative disease characterized by the accumulation of toxic amyloid beta (Aβ) peptide within the brain. APP plays an important role in AD, as the Aβ is formed when APP is sequentially cleaved by β- and γ-secretase. This is known as amyloidogenic processing of APP. LÄS MER

  4. 8. Processing of TNF-receptors to soluble receptor forms in myeloid cells

    Författare :Flemming Björnberg; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; inflammation cytokine TNF receptor; extracellular fluids; Haematology; Hematologi; extracellulära vätskor;

    Sammanfattning : TNF (Tumor Necrosis Factor) is a pro-inflammatory cytokine which binds to two cell surface receptors, TNF-R55 and TNF-R75. The receptors undergo proteolytic cleavage and release a fragment (soluble TNF-receptors or TNF-Binding Protein), TNF-R55-BP and TNF-R75-BP. Soluble TNF-receptors are able to bind and inactivate TNF. LÄS MER

  5. 9. Spleno-pancreatic development assessed by 3D molecular imaging

    Författare :Amir Asayesh; Ulf Ahlgren; Beatriz Sosa-Pineda; Umeå universitet; []
    Nyckelord :Cell biology; Spleen; Pancreas; Imaging; Development; Cellbiologi; miljömedicinsk utvecklingsbiologi; Developmental Biology;

    Sammanfattning : The development of different organs and tissues along the gastrointestinal tract, including the pancreas, depends on signalling between the endoderm and the adjacent mesenchyme. The Nkx gene Bapx1 is involved in spatial control of organ-positioning in the spleno-pancreatic region, and deficiency in this gene results in unacceptable proximity of the splenic mesenchyme to the pancreas. LÄS MER

  7. 10. Aggrecan fragments as biomarkers in osteoarthritis

    Författare :Staffan Larsson; Lund Ortopedi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protease; Aggrecan; osteoarthritis; proteoglycan; knee injury; biomarker; aggrecanase;

    Sammanfattning : Background: In osteoarthritis (OA) the balance of cartilage matrix synthesis and degradation is disturbed, resulting in a gradual destruction of the articular cartilage. Matrix components released into body fluids by proteolytic cleavage can be used as biomarkers of ongoing processes. LÄS MER