Sökning: "Mass spectrometry"

Visar resultat 11 - 15 av 1137 avhandlingar innehållade orden Mass spectrometry.

  1. 11. An Organic Chemistry Odyssey : Imaging Mass Spectrometry in Neurotherapeutics, Asymmetric Methodology Development and Natural Product Synthesis

    Författare :Marvin Villacrez; Kemisk biologi med inriktning mot läkemedelsutveckling; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Masspektrometri; totalsyntes; avbildande massspektrometri; MALDI avbildande massspektrometri; asymmetrisk syntes; farmakokinetik; dynamisk kinetisk resolution; Aasymetrisk överföringshydrogenering; klozapin; Läkemedelsmetabolism; läkemedelsdistribution; aminoalkoholer; Aspidophylline A; mass spectromery; Imaging mass spectrometry; Total synthesis; Dynamic kinetic resolution; asymmetric transfer hydrogenation; Aspidophylline A; Drug distribution; Drug metabolism; Drug Metabolism and Mass Spectrometry Imaging; MALDI mass spectrometry imaging; clozapine; amino alcohols; pharmacokinetics;

    Sammanfattning : The development of imaging technologies and brain models is crucial for advancements in neurotherapeutic drug discovery and development. They assume a critical role in evaluating essential parameters such as drug blood-brain barrier (BBB) permeation, distribution, and metabolism, all of which are vital for the development of safe and effective medications. LÄS MER

  3. 12. Mass spectrometry of proteins

    Författare :Ivan Kamensky; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

    Sammanfattning : .... LÄS MER

  4. 13. Chiral Recognition by Means of Mass Spectrometry

    Författare :Oleksii Rebrov; Mats Larsson; Per Johnsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chirality; Mass spectrometry; Chiral recognition; Gas phase; kemisk fysik; Chemical Physics;

    Sammanfattning : This thesis is based on experimental studies of chiral ions in gas-phase. Electrospray ion source platform (Stockholm University) and commercially available Quadrupole Time-of-Flight mass spectrometer have been used in our studies. LÄS MER

  5. 14. Mass Spectrometry of Biologically Active Small Molecules : Focusing on polyphenols, alkaloids and amino acids

    Författare :Zdeněk Spáčil; Leopold L. Ilag; Frantisek Turecek; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; LC-MS; LDI; Mass spectrometry; HPLC; UHPLC; polyphenols; phenolic acids; BMAA; Separation methods; Separationsmetoder; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

    Sammanfattning : The foci of this dissertation are on advanced liquid chromatography (LC) separation and mass spectrometry (MS) techniques for the analysis of small bioactive molecules. In addition to discussing general aspects of such techniques the results from analyses of polyphenols (PPs), alkaloids and amino acids published in five appended studies are presented and discussed. LÄS MER

  7. 15. Secondary and Higher Order Structural Characterization of Peptides and Proteins by Mass Spectrometry

    Författare :Christopher Adams; Roman Zubarev; Göran Possnert; Carlito Lebrilla; Uppsala universitet; []
    Nyckelord :Engineering physics; Protein Structure; Mass Spectrometry; Electron Capture Dissociation; Tandem Mass Spectrometry; Teknisk fysik;

    Sammanfattning : The work in this thesis has demonstrated the advantages and limitations of using MS based technologies in protein and peptide structural studies. Tandem MS, specifically electron capture dissociation (ECD) have shown the ability to provide structural insights in molecules containing the slightest of all modifications (D-AA substitution). LÄS MER